PMID: 8966681Oct 1, 1996Paper

Current knowledge in the etiology of arthritis

Therapeutische Umschau. Revue thérapeutique
H J Häuselmann

Abstract

Osteoarthritis (OA) is a disease process with common risk factors and a variable outcome. The disease process that leads to OA includes factors that are driving degradation in focal areas of articular cartilage and attempted repair processes in the cartilage, subchondral bone, and soft tissues. The individual risk factors for OA lead to a generalized predisposition to the condition, and, together with factors resulting in abnormal biomechanical loading at specific joint sites, they result in disease. There is not only progress in researching etiologic factors in OA (recently discovered collagen type II gene mutations), but there has been considerable progress in recent years regarding the fine details of matrix degradation and its regulation. One is the finding of a hypermetabolic state of matrix turnover early in OA, suggesting an accelerated damage to the newly synthesized molecules over what is observed in healthy cartilage. This sustained damage of matrix molecules slowly leads to a loss of tissue. Further recently elucidated biochemical and biomechanical factors will be discussed.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Seminars in Perinatology
Arthur I Eidelman, Arnon Samueloff
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
Shu-Juan Zheng, Chi-Yu Jia
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
John Yarnold, Marie-Catherine Vozenin Brotons
Frontiers in Bioscience (Scholar Edition)
Sandra AmaralJoao Ramalho-Santos
© 2021 Meta ULC. All rights reserved