Current knowledge on diabetic retinopathy from human donor tissues

World Journal of Diabetes
Jessica H EismaPatrice E Fort

Abstract

According to the American Diabetes Association, diabetes was the seventh leading cause of death, and diabetic retinopathy the leading cause of blindness in working age adults in the United States in 2010. Diabetes is characterized by hyperglycemia associated with either hypoinsulinemia or insulin resistance, and over time, this chronic metabolic condition may lead to various complications including kidney failure, heart attacks, and retinal degeneration. In order to better understand the molecular basis of this disease and its complications, animal models have been the primary approach used to investigate the effects of diabetes on various tissues or cell types of the body, including the retina. However, inherent to these animal models are critical limitations that make the insight gained from these models challenging to apply to the human pathology. These difficulties in translating the knowledge obtained from animal studies have led a growing number of research groups to explore the diabetes complications, especially diabetic retinopathy, on tissues from human donors. This review summarizes the data collected from diabetic patients at various stages of diabetic retinopathy and classifies the data based upon their relevance to...Continue Reading

Citations

Oct 4, 2015·Progress in Retinal and Eye Research·Helen V Danesh-MeyerColin R Green
Sep 20, 2015·American Journal of Ophthalmology·Richard F Spaide
Apr 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Elliott H SohnMichael David Abràmoff
Aug 16, 2016·Acta Ophthalmologica·Johanna SchmidtMartin Hammer
Apr 14, 2017·Vision Research·Alexander V Ljubimov

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