Current laboratory diagnosis of coronavirus disease 2019

The Korean Journal of Internal Medicine
Jihyang Lim, Jehoon Lee

Abstract

Coronavirus disease 2019 (COVID-19) emerged in December 2019 in Wuhan, China; it has since caused a pandemic, with more than 10,000 confirmed cases (> 800,000 tests) in Korea as of May 2020. Real-time reverse transcription polymerase chain reaction (RT-PCR) is currently the most commonly used method for the diagnosis of COVID-19 worldwide. The Korean Society for Laboratory Medicine and Korea Centers for Disease Prevention and Control regularly update the guidelines for COVID-19 diagnosis. Emergency use authorization for some laboratory diagnostic kits has been granted, enabling the timely diagnosis and treatment of COVID-19, and the isolation of infected patients. Due to the collective efforts of the government, medical professionals, local authorities, and the public, Korea's response to the COVID-19 outbreak has been accepted widely as a model. Here, we summarize the currently available laboratory tests for COVID-19 diagnosis. Although RT-PCR tests are used widely to confirm COVID-19, antibody tests could provide information about immune responses to the virus.

References

Dec 7, 2018·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F MaggiG Antonelli
Jan 28, 2020·Journal of Drug Targeting·Shaheen SultanaNasir Ali Siddiqui
Feb 13, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kelvin Kai-Wang ToKwok-Yung Yuen
Feb 28, 2020·JAMA : the Journal of the American Medical Association·Lan LanHaibo Xu
Mar 12, 2020·JAMA : the Journal of the American Medical Association·Wenling WangWenjie Tan
Mar 14, 2020·The Journal of Clinical Investigation·Arturo Casadevall, Liise-Anne Pirofski
Mar 17, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe LippiMario Plebani
Mar 20, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe Lippi, Mario Plebani
Mar 22, 2020·Journal of Clinical Pathology·Shaun S TanSunil Sethi
Mar 22, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Li GuoJianwei Wang
Apr 1, 2020·Journal of Medical Virology·Irene CassanitiUNKNOWN Members of the San Matteo Pavia COVID-19 Task Force
Apr 3, 2020·Drug and Therapeutics Bulletin
Apr 3, 2020·JAMA : the Journal of the American Medical Association·Joseph HadayaEdward H Livingston
Apr 3, 2020·Annals of Laboratory Medicine·Young Jin KimMina Hur
Apr 16, 2020·Journal of Medical Virology·Guangshu Han, Yi-Hua Zhou
Apr 16, 2020·The New England Journal of Medicine·Abrar-Ahmad ZulfiqarEmmanuel Andrès
Apr 18, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Andrea PadoanMario Plebani
Apr 20, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fei XiangWan-Li Ma
Apr 21, 2020·International Journal of Laboratory Hematology·John L FraterHeesun J Rogers
Apr 21, 2020·Annals of Laboratory Medicine·Young Jin KimMina Hur
Apr 21, 2020·Annals of Laboratory Medicine·Ki Ho HongCheon Kwon Yoo
Apr 30, 2020·Journal of Medical Virology·Hongzhou LuYi-Wei Tang
May 1, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
Jun 9, 2020·Annals of the Royal College of Surgeons of England·G S Kainth

❮ Previous
Next ❯

Citations

Mar 11, 2021·Journal of Immunoassay & Immunochemistry·Ahamed Basha Abdul Bari, Prince Johnson Samuel
Apr 2, 2021·Frontiers in Microbiology·Tyler SeckarErle S Robertson
May 2, 2021·Postgraduate Medical Journal·Bahar HassanmirzaeiNavid Moghadam
Aug 3, 2021·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Georgios MeletisLemonia Skoura
Aug 21, 2021·Computers in Biology and Medicine·Yunus Emre Erdoğan, Ali Narin
Sep 28, 2021·ACS Infectious Diseases·Hyunju OhAnubhav Tripathi

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar
lavage
nucleic acid extraction
PCR
biopsy
enzyme-linked immunosorbent assay

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives of Iranian Medicine
Xiaoyi HuangKen Chen
Infection and Drug Resistance
Amin Sadeghi DousariNaghmeh Satarzadeh
Canadian Respiratory Journal : Journal of the Canadian Thoracic Society
Houdong Zuo
© 2021 Meta ULC. All rights reserved