Current laboratory techniques in the diagnosis of catheter-related infections

Nutrition
J LiñaresR Martín

Abstract

The unspecificity of the clinical manifestations of catheter-related infections (CRIs) makes laboratory confirmation necessary, and many diagnostic techniques have been developed. Semiquantitative culture of catheter tips has been accepted by most laboratories for its simplicity and is currently the reference technique. It discriminates between catheters producing infection (when > or = 15 colony forming units grow on the culture) and insignificant colonization. Nonquantitative methods improve the sensitivity of diagnosis of CRI but are less specific. Quantitative methods improve the specificity and can identify and quantify colonization of both the internal and external surfaces of the catheter; however, these are time-consuming techniques. The high rate of unnecessary catheter removal has promoted interest in in situ staining methods such as gram staining of the skin entry site and hub. These methods are simple to perform and have shown a high negative predictive value. Quantitative blood culture methods allow the diagnosis of CRI, but their sensitivity decreases in the absence of associated bacteremia. Finally, the introduction of molecular techniques has helped to explain the pathogenesis of CRI and could help to improve th...Continue Reading

References

Apr 1, 1979·Archives of Internal Medicine·E J WingA Winkelstein
Jun 9, 1977·The New England Journal of Medicine·D G MakiH W Sarafin
May 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J A CapdevilaJ M Martínez-Vázquez
Aug 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I I Raad, G P Bodey
Jan 1, 1992·Diagnostic Microbiology and Infectious Disease·I I RaadR J Sherertz
Jan 1, 1991·Scandinavian Journal of Infectious Diseases·J RelloG Prats
Jul 1, 1990·Archives of Internal Medicine·E CercenadoE Bouza
Sep 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P J Collignon, R Munro
May 2, 1985·The New England Journal of Medicine·G L Cooper, C C Hopkins
Oct 1, 1988·The Journal of Hospital Infection·S T FanK K Wong
Jan 1, 1986·Pediatric Infectious Disease·A PrinceW C Heird
May 1, 1987·Archives of Internal Medicine·C Brun-BuissonM Rapin
Aug 1, 1987·The Pediatric Infectious Disease Journal·P M FlynnF F Barrett
Mar 1, 1985·Surgery·A Sitges-SerraJ Garau
May 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·A Sitges-SerraL Lorente
May 1, 1985·The Journal of Antimicrobial Chemotherapy·A Sitges-SerraS Capell
Apr 4, 1974·The New England Journal of Medicine·J A RyanJ E Fischer
Jun 1, 1980·The Journal of Infectious Diseases·D J CleriS J Seligman
Mar 1, 1981·The American Journal of Medicine·D G Maki
Aug 14, 1993·Lancet·J A RushforthJ W Puntis

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Citations

Oct 20, 2010·BMC Microbiology·Li ZhangClaire M Rickard
Oct 14, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J Maroulis, F Kalfarentzos
Nov 13, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G FätkenheuerH Seifert
Jul 2, 2008·Clinical Orthopaedics and Related Research·Jesse E BibleJonathan N Grauer
Jun 18, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M A LivesleyT S Elliott
Jan 7, 2014·Clinical and Vaccine Immunology : CVI·Nathaniel D LambertGregory A Poland
Sep 23, 2020·The Cochrane Database of Systematic Reviews·Vimal Scott KapoorS Swaroop Vedula

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