Current management of polycythemia vera

Leukemia & Lymphoma
Ayalew Tefferi

Abstract

Over a century has elapsed since the first description of polycythemia vera (PV), and current treatment recommendations are primarily based on the results of clinical trials that were performed in the late 1960s and early 1970s. Continued identification and appropriate utilization of PV-specific biologic parameters may allow substantial modification of early diagnostic criteria. New cytoreductive treatment agents are increasingly being used without any evidence of superiority over conventional therapy. The role of aspirin is being readdressed by an ongoing controlled study. Transformation of PV into either myelofibrosis with myeloid metaplasia or acute leukemia remains a major complication that may not be influenced by current therapy.

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Citations

Jun 26, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Hans Michael Kvasnicka, Jürgen Thiele
Dec 2, 2006·Drugs·Elisabeth I Penninga, Ole W Bjerrum
Oct 21, 2003·Leukemia & Lymphoma·Francesco Passamonti, Mario Lazzarino
Nov 16, 2004·The American Journal of Medicine·Francesco PassamontiMario Lazzarino
Jun 11, 2004·Seminars in Hematology·Jerry L Spivak
Oct 8, 2005·Seminars in Hematology·Juergen ThieleAttilio Orazi
Oct 8, 2005·Seminars in Hematology·Ayalew Tefferi, Jerry L Spivak
Oct 8, 2005·Seminars in Hematology·Zhizhuang Joe ZhaoStefan N Constantinescu

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