PMID: 15378129Sep 21, 2004Paper

Current medical management of chronic stable angina

Journal of Cardiovascular Pharmacology and Therapeutics
Udho Thadani

Abstract

Severe atherosclerotic narrowing of one or more coronary arteries is responsible for myocardial ischemia and angina pectoris in most patients with stable angina. The coronary arteries of patients with stable angina also contain many more non-obstructive plaques, which are prone to rupture resulting in acute coronary syndrome (unstable angina, myocardial infarction, sudden ischemic death). Therefore, the medical management must use strategies which not only relieve symptoms and prolong angina free walking but also reduce the incidence of adverse clinical outcomes. Whether any of the approved antianginal drugs, nitrates, beta-blockers, and calcium channel blockers reduce the incidence of adverse clinical outcomes in patients with stable angina has not been studied to date. Published data shows that percutaneous coronary revascularization procedures and coronary bypass surgery are effective in relieving angina but these procedures do not reduce mortality or the incidence of myocardial infarction compared to anti-anginal drug therapy. From the available data, an initial trial of medical treatment with anti-anginal drugs and strategies to reduce adverse clinical outcomes (smoking cessation, daily aspirin, treatment of dyslipidemias ...Continue Reading

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Citations

Nov 14, 2007·American Journal of Pharmaceutical Education·Stephen T O'Rourke
Jan 13, 2006·Current Treatment Options in Cardiovascular Medicine·Udho Thadani
Feb 2, 2006·Expert Opinion on Pharmacotherapy·Eric H Yang, Gregory W Barsness
Nov 13, 2007·The American Journal of Cardiology·Giancarlo LongobardiNicola Ferrara
Nov 16, 2005·Journal of the American College of Cardiology·Ralph M VicariUNKNOWN Fasudil Study Group
Sep 18, 2016·Cardiovascular Drugs and Therapy·Udho Thadani
Jan 26, 2017·Drugs·Talla A RousanUdho Thadani
May 20, 2015·JAAPA : Official Journal of the American Academy of Physician Assistants·Deepali Dixit, Katarzyna Kimborowicz
Nov 3, 2005·Nature Clinical Practice. Cardiovascular Medicine·Udho Thadani
Oct 12, 2005·Circulation·Jonathan Abrams, Udho Thadani
May 27, 2015·Nature Reviews. Cardiology·Jenna DeanC Noel Bairey Merz
Sep 17, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Shaojun LiaoZehuai Wen

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