Current methods for attaching targeting ligands to liposomes and nanoparticles

Journal of Pharmaceutical Sciences
Leila NobsEric Allémann

Abstract

Liposomes and nanoparticles have emerged as versatile carrier systems for delivering active molecules in the organism. These colloidal particles have demonstrated enhanced efficacy compared to conventional drugs. However, the design of liposomes and nanoparticles with a prolonged circulation time and ability to deliver active compounds specifically to target sites remains an ongoing research goal. One interesting way to achieve active targeting is to attach ligands, such as monoclonal antibodies or peptides, to the carrier. These surface-bound ligands recognize and bind specifically to target cells. To this end, various techniques have been described, including covalent and noncovalent approaches. Both in vitro and in vivo studies have proved the efficacy of the concept of active targeting. The present review summarizes the most common coupling techniques developed for binding homing moieties to the surface of liposomes and nanoparticles. Various coupling methods, covalent and noncovalent, will be reviewed, with emphasis on the major differences between the coupling reactions, on their advantages and drawbacks, on the coupling efficiency obtained, and on the importance of combining active targeting with long-circulating particles.

References

Aug 28, 1979·Biochemical and Biophysical Research Communications·V P TorchilinE Haber
May 1, 1979·Biochemistry·L Huang, S J Kennel
Dec 14, 1978·Biochemical and Biophysical Research Communications·V P TorchilinV N Smirnov
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G WeissmannD Nagle
Jun 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V P TorchilinB A Khaw
Jun 1, 1991·Analytical Biochemistry·I Pieri, D Barritault
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D PapahadjopoulosC Redemann
Nov 1, 1990·Journal of Pharmaceutical Sciences·K MaruyamaL Huang
Dec 29, 1989·Biochemical and Biophysical Research Communications·E HolmbergL Huang
Sep 16, 1988·Biochimica Et Biophysica Acta·J T DerksenG L Scherphof
Jul 10, 1987·Biochimica Et Biophysica Acta·H LoughreyP R Cullis
Jul 30, 1985·Biochimica Et Biophysica Acta·V O IvanovV N Smirnov
Nov 18, 1980·Biochimica Et Biophysica Acta·V P TorchilinV N Smirnov
Aug 21, 1984·Biochimica Et Biophysica Acta·M M ChuaF Karush
Nov 1, 1983·Analytical Biochemistry·S Carpenter-Green, L Huang
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L D LesermanW D Terry
Jul 14, 1982·Biochimica Et Biophysica Acta·D F ShenL Huang
Dec 15, 1981·Biochemical and Biophysical Research Communications·M HarschH G Weder
Apr 12, 1995·Biochimica Et Biophysica Acta·U K NässanderG Storm
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·J W ParkW I Wood
Mar 18, 1994·Science·R GrefR Langer
May 1, 1997·Pharmaceutical Research·N HussainA T Florence
Jan 1, 1997·Advances in Pharmacology·J W ParkC C Benz
Jul 1, 1997·Journal of Pharmaceutical Sciences·P CrosassoL Cattel
Jul 25, 1997·Biochimica Et Biophysica Acta·J A HardingS Zalipsky
Feb 12, 1998·Cancer Letters·J W ParkC C Benz
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S K HobbsR K Jain
Aug 5, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J PortnoyC Barnes

❮ Previous
Next ❯

Citations

Jul 5, 2006·Cancer Immunology, Immunotherapy : CII·Keith L KnutsonLupe G Salazar
May 21, 2005·Pharmaceutical Research·Ali AzhdariniaE Edmund Kim
May 30, 2008·Pharmaceutical Research·Christopher D HeinDong Wang
Dec 25, 2008·Pharmaceutical Research·Christine Vauthier, Kawthar Bouchemal
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jeffrey D KingsleyChristopher J Destache
May 23, 2009·Chemical Communications : Chem Comm·Hailong ZhangXue-Long Sun
Nov 4, 2008·Medical Physics·Naomi Matsuura, J A Rowlands
Apr 15, 2011·Journal of Drug Delivery·Maluta S MufamadiValence M K Ndesendo
Mar 20, 2009·The AAPS Journal·Bo YuRobert J Lee
Mar 30, 2011·International Journal of Nanomedicine·Jun WangXuemei Wang
Jan 10, 2012·International Journal of Nanomedicine·Andrea L Armstead, Bingyun Li
Mar 6, 2013·International Journal of Nanomedicine·Hongkee SahGeorge C Wood
Nov 3, 2010·Nanomedicine·Jie GaoYajun Guo
Jul 19, 2012·Pharmaceutical Research·Katica StojanovErik F J de Vries
Dec 14, 2011·Expert Review of Vaccines·Delaram Doroud, Sima Rafati
Feb 21, 2016·Colloids and Surfaces. B, Biointerfaces·Fikret AydinMeenakshi Dutt
Mar 17, 2007·Journal of Drug Targeting·Barbara StellaJack-Michel Renoir
Oct 2, 2014·Expert Opinion on Drug Delivery·Michael J Mitchell, Michael R King
Dec 22, 2007·Expert Opinion on Drug Delivery·Ben J Boyd
Oct 20, 2006·Journal of Drug Targeting·Ronny RügerRoland E Kontermann
Oct 26, 2011·Journal of Drug Targeting·Carla G MoutinhoVictor M Balcão
Nov 29, 2007·Journal of Drug Targeting·Christine VauthierGilles Ponchel
Nov 26, 2005·Journal of Drug Targeting·Ronny RügerRoland E Kontermann
Nov 26, 2013·FEBS Letters·V A Petrenko, P K Jayanna
May 13, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aditya G KohliFrancis C Szoka
Jan 18, 2008·Journal of Pharmaceutical Sciences·Ales Prokop, Jeffrey M Davidson
Jan 17, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Virginia J YaoRenata Pasqualini
Dec 20, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Yuan-Chia KuoSrinivasa R Raghavan
May 30, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Stephen R GrobmyerSteven N Hochwald
Mar 10, 2012·Maturitas·Stephen R GrobmyerSteven N Hochwald

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.