Current Methods for the Treatment and Prevention of Drug-Induced Parkinsonism and Tardive Dyskinesia in the Elderly

Drugs & Aging
Carlos Estevez-FragaJose L López-Sendón Moreno

Abstract

Drug-induced parkinsonism (DIP) and tardive dyskinesia (TD) are iatrogenic consequences of antidopaminergic drugs. Both are particularly prevalent among the elderly and those with dementia. However, despite their prevalence, these disorders are often overlooked. Both entities share risk factors, physiopathological mechanisms and, to some degree, therapeutic approaches. Withdrawing the causal agent, reducing the dose or switching to a less potent antidopaminergic drug should be the first therapeutic options. Here we review both entities and emerging therapies including the recently approved drugs deutetrabenazine and valbenazine. We discuss relevant aspects for clinical practice such as new diagnostic techniques and the latest advances in the understanding of DIP and TD.

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Related Concepts

Valbenazine
Deutetrabenazine
Tardive Dyskinesia
Senile Paranoid Dementia
Dyskinesia, Medication-Induced
Xenazine
Valine
Ramsay Hunt Paralysis Syndrome
Prophylactic Treatment
Parkinsonism due to Drug

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