Dec 7, 2019

Current opinion neurology: visual pathway biomarkers in Alzheimer's disease

Current Opinion in Neurology
Gregory P Van Stavern


The incidence of Alzheimer's disease is increasing. Premortem diagnosis of Alzheimer's disease is now possible but require invasive and expensive testing such as PET amyloid beta binding and/or spinal fluid amyloid beta levels. There is a great need for minimally invasive and inexpensive biomarkers to allow for early diagnosis and intervention. There has been a large volume of literature assessing ocular biomarkers for Alzheimer's disease. Much of the research to date has significant limitations, including sample size, variable diagnostic criteria for Alzheimer's disease, lack of biomarker assessment, and focus on patients with well established dementia. Work that is more recent has included individuals with early and preclinical Alzheimer's disease with biomarkers included in the design. These studies have shown consistent features of visual pathway involvement in Alzheimer's disease, even in the earliest and preclinical stages. It is possible that in the future, ocular biomarkers (particularly retinal imaging techniques) may be part of a multimodality alogorithm screening for preclinical Alzheimer's disease, perhaps combined with other methods, such as blood-based biomarkers.

  • References45
  • Citations


  • References45
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Biological Markers
Positron-Emission Tomography
Disorder of Visual Pathways
Cerebrospinal Fluid
Alzheimer's Disease
Imaging Techniques

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Neuroimaging

Alzheimer's disease (AD) is a chronic neurodegenerative disease. Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
C S EkeE Ifeachor
BioRxiv : the Preprint Server for Biology
Benjamin GoudeyNoel G Faux
Critical Reviews in Clinical Laboratory Sciences
Peter D Fransquet, Joanne Ryan
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Eva CarroGorka Orive
© 2020 Meta ULC. All rights reserved