Current pathophysiological developments in fibrosing diseases: insights into novel treatment concepts

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
S A Eming

Abstract

Fibrosis is a common symptom of a variety of skin disorders of diverse entity. The cellular and molecular pathophysiology of fibrosis development is unresolved and current treatment options are not sufficient. Tissue fibrosis leads to increased tissue stiffness, impaired organ function, decline of quality of life and ultimately increased morbidity and mortality. Epidemiologic studies indicate that nearly 45% of all deaths in the western world are associated with tissue fibrosis in diverse organs. Only few recently approved treatment options specifically target the process of fibrogenesis. The development of novel and efficient therapies is urgently needed, and at the same time provides a major challenge but also an opportunity to contribute to the advancement of this unresolved medical problem. This article highlights recent insights in the developments on tissue fibrosis with a focus on immunoregulatory mechanisms.

References

Dec 29, 2007·The Journal of Pathology·T A Wynn
Jul 17, 2008·Nature Reviews. Molecular Cell Biology·Matthias Schäfer, Sabine Werner
May 8, 2009·The New England Journal of Medicine·Armando GabrielliThomas Krieg
May 2, 2013·Journal of Dermatological Science·Johanna CanadyAnja K Bosserhoff
Oct 17, 2014·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A BrownS A Eming
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kory J LavineDouglas L Mann
Dec 4, 2014·Nature·Elisa Gomez PerdigueroHans-Reimer Rodewald
Dec 5, 2014·Science Translational Medicine·Sabine A EmingMarjana Tomic-Canic
Feb 11, 2015·The Journal of Clinical Investigation·Yulong ChenJonathan M Kurie
Aug 10, 2015·Cytokine·Richard D May, Michael Fung
Nov 26, 2015·Nature Reviews. Immunology·Yonit LavinMiriam Merad
Aug 6, 2016·Science·Elvira MassFrederic Geissmann
Sep 17, 2016·Arthritis & Rheumatology·Jörg H W DistlerDavid J Abraham
Jun 10, 2017·Science·Sabine A EmingPaul Martin
Feb 2, 2018·Science Translational Medicine·Dario R Lemos, Jeremy S Duffield
Feb 7, 2018·Matrix Biology : Journal of the International Society for Matrix Biology·Jan-Niklas SchulzBeate Eckes
May 22, 2018·The New England Journal of Medicine·Klaus F RabeAriel Teper

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