Current perspectives of mi-RNA in oesophageal adenocarcinoma: Roles in predicting carcinogenesis, progression and values in clinical management

Experimental and Molecular Pathology
Moein Amin, Alfred King-Yin Lam

Abstract

Aberrant expressions of micro-ribonucleic acids (miRs) are closely associated with the pathogenesis in many human cancers. In oesophageal adenocarcinomas, altered expressions of different sets of miRs are noted to be associated with the development of adenocarcinoma from Barrett's oesophagus. In different studies, miRs such as miR-192, miR-196 and miR-21 were frequently noted to up-regulated whereas miR-203, miR-205 and miR-let-7 were commonly down-regulated during the development of Barrett's oesophagus to oesophageal adenocarcinoma. In addition, changes in the expression of miRs are associated with the predication of metastasis, prognosis and response to chemo-radiation in the patients with oesophageal adenocarcinoma. Experimental studies in manipulating the miRs in cancer cell lines could provide hints for therapeutics for the cancer. However, the number of studies reported on these aspects of oesophageal adenocarcinoma was limited and the miRs noted needed to be confirmed by additional studies. Overall, the mechanisms of involvements of miRs in pathogenesis and progression of oesophageal adenocarcinoma are complex. Although miRs have the potential to act as prognostic and clinical biomarkers for cancer therapy in oesophagea...Continue Reading

References

Jul 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K Y LamJ Wong
Jan 6, 2006·Journal of Clinical Pathology·K W ChanG Srivastava
Feb 5, 2008·The Journal of Thoracic and Cardiovascular Surgery·Andrew FeberVirginia R Litle
Sep 10, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hushan YangXifeng Wu
Oct 1, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ewy A MathéCurtis C Harris
Mar 20, 2010·The British Journal of Surgery·B P L WijnhovenUNKNOWN South Australian Oesophageal Research Group
Mar 24, 2010·International Journal of Cancer. Journal International Du Cancer·Yuxin HuXiao-Chun Xu
Aug 13, 2010·Journal of Clinical Pathology·Matteo FassanMassimo Rugge
Oct 16, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giang Huong NguyenCurtis C Harris
Dec 4, 2010·International Journal of Cancer. Journal International Du Cancer·Matteo FassanMassimo Rugge
Mar 23, 2011·The Annals of Thoracic Surgery·Andrew FeberVirginia R Litle
Feb 4, 2012·Genes, Chromosomes & Cancer·Rom S LeidnerKishore Guda
Apr 17, 2012·Gut·Jantine W P M van BaalPeter D Siersema
Jun 19, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Niamh Lynam-LennonStephen G Maher
Sep 4, 2012·The Annals of Thoracic Surgery·Michael Augustine KoGail E Darling
Apr 27, 2013·Human Pathology·Matteo FassanMassimo Rugge
May 21, 2013·World Journal of Gastroenterology : WJG·Dessy ChanJohnny Cheuk-On Tang
Jun 13, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mirte Mayke StreppelAnirban Maitra
Aug 9, 2013·Digestive Diseases and Sciences·Katherine S GarmanNicholas J Shaheen
Dec 26, 2013·Experimental and Molecular Pathology·Faeza EbrahimiAlfred King-Yin Lam
Aug 8, 2014·Experimental and Molecular Pathology·Hamidreza MaroofAlfred King-Yin Lam
Aug 17, 2014·Experimental Cell Research·Vinod GopalanAlfred K-Y Lam
Oct 21, 2014·Current Cancer Drug Targets·Hamidreza MaroofAlfred King-Yin Lam

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Citations

Sep 1, 2015·Experimental and Molecular Pathology·Anna Chruścik, Alfred King-Yin Lam
Oct 13, 2015·Experimental Cell Research·Faeza EbrahimiAlfred King-Yin Lam
Sep 6, 2015·Journal of Molecular Endocrinology·Ali SalajeghehAlfred King-Yin Lam
May 18, 2016·Critical Reviews in Oncology/hematology·Katherine Ting-Wei LeeSook-Yee Gan
Sep 14, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yinan MaMinghua Bai
Oct 25, 2016·Experimental Cell Research·Vinod GopalanAlfred King-Yin Lam
Aug 26, 2017·Expert Review of Gastroenterology & Hepatology·Wanli YangLiu Hong
Jan 13, 2016·World Journal of Gastroenterology : WJG·Christine KestensJantine W P M van Baal
May 23, 2018·Journal of Translational Medicine·Tiphaine de FoucherCyril Touboul
Dec 26, 2018·Journal of Cellular Biochemistry·Yuemei YangWeiliang Ye

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