Current perspectives on cytokines for anti-retroviral therapy in AIDS related B-cell lymphomas

Current Drug Targets. Infectious Disorders
V Sharma

Abstract

The development of high-grade B-cell lymphoma in Acquired Immunodeficiency Syndrome (AIDS) patients is a relatively late manifestation induced by Human Immunodeficiency Virus-1 (HIV) infection and is considered to be an AIDS-defining condition. Multiple, ongoing molecular and cytogenetic aberrations appear necessary for the development of AIDS-related lymphoma. Studying a panel of human B-cell lines derived from patients with Burkitt's lymphoma (BL) and AIDS-associated Burkitt's lymphoma (AIDS-BL) we had described constitutive expression and secretion of large amounts of Interleukin-16 (IL-16), Macrophage Inflammatory Protein-1alpha (MIP-1alpha), Macrophage Inflammatory Protein-1beta (MIP-1beta), Interleukin-12 (IL-12), Interleukin-10 (IL-10), and Interleukin-7 (IL-7). Some of these cytokines like IL-16, MIP-1beta, MIP-1alpha and Regulated upon activation normal T expressed and secreted (RANTES) are shown to have inhibitory effect on HIV replication. Interestingly, we identified a novel transcription factor family, Macrophage Inflammatory Protein-1alpha Nuclear Protein (MNP), which is suggested as a potential target for anti-retroviral therapy based on the implication of its role and involvement as a key regulator of MIP-1alpha...Continue Reading

Citations

Nov 15, 2006·Clinical and Experimental Immunology·K TsukamotoV Sharma
Aug 9, 2005·Biochemical and Biophysical Research Communications·Yi-Chun HuangVenkatanarayanan Sharma
Jun 27, 2020·Nanomedicine·Emmanuel Shan OnaiviVenkatanarayanan Sharma
Sep 26, 2020·Future Science OA·Emmanuel Shan Onaivi, Venkatanarayanan Sharma

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