Current perspectives on obesity and skeletal muscle contractile function in older adults.

Journal of Applied Physiology
Chad R StraightMark S Miller

Abstract

Obesity has become one of the most pressing public health issues of the 21st century and currently affects a substantial proportion of the older adult population. Although the cardiometabolic complications are well documented, research from the past 20 years has drawn attention to the detrimental effects of obesity on physical performance in older adults. Obesity-related declines in physical performance are due, in part, to compromised muscle strength and power. Recent evidence suggests there are a number of mechanisms potentially underlying reduced whole muscle function, including alterations in myofilament protein function and cellular contractile properties, and these may be related to morphological adaptations, such as shifts in fiber type composition and increased intramyocellular lipid content within skeletal muscle. To date, even less research has focused on how exercise and weight loss interventions for obese older adults affect these mechanisms. In light of this work, we provide an update on the current knowledge related to obesity and skeletal muscle contractile function and highlight a number of questions to address potential etiologic mechanisms as well as intervention strategies, which may help advance our understa...Continue Reading

References

Aug 1, 1994·Journal of Applied Physiology·S Schiaffino, C Reggiani
Sep 1, 1996·Pflügers Archiv : European journal of physiology·S D HarridgeB Saltin
May 18, 2001·Journal of Applied Physiology·B H GoodpasterA B Newman
Sep 26, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P MalenfantJ A Simoneau
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Charles J TannerJoseph A Houmard
Feb 18, 2003·Journal of the American Geriatrics Society·Anne B NewmanUNKNOWN Health Aging And Body Composition Research Group
Dec 25, 2003·Diabetes·John M AdamsLawrence J Mandarino
Dec 17, 2004·Pediatric Diabetes·Bret H Goodpaster, Donna Wolf
Feb 4, 2009·The Journal of Clinical Investigation·Ethan J AndersonP Darrell Neufer
Mar 12, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Peter ChomentowskiBret H Goodpaster
Oct 22, 2011·Exercise and Sport Sciences Reviews·Kieran F Reid, Roger A Fielding
Dec 12, 2012·Epidemiologic Reviews·Laura A SchaapMarjolein Visser
Feb 9, 2013·Exercise and Sport Sciences Reviews·Mark S Miller, Michael J Toth
Sep 26, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Seung J ChoiOsvaldo Delbono
Sep 29, 2015·Trends in Endocrinology and Metabolism : TEM·Bhagirath Chaurasia, Scott A Summers
Feb 26, 2016·Proceedings of the National Academy of Sciences of the United States of America·Michael J PrevisRoger Craig
Feb 16, 2017·Journal of Cachexia, Sarcopenia and Muscle·Elisa FabbriLuigi Ferrucci
Mar 25, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F SeebacherR S James
Jan 18, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrew W Frank-WilsonUNKNOWN AGES-Reykjavik Study
Mar 17, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zhong-Min WangOsvaldo Delbono
Jul 8, 2018·The Journal of Experimental Biology·Jason TallisFrank Seebacher
Aug 2, 2018·Nature Reviews. Endocrinology·John A Batsis, Dennis T Villareal
Nov 15, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chad R StraightMark S Miller
Jan 24, 2020·Journal of Women's Health·Matthew E ArnegardJanine Austin Clayton
Jan 29, 2020·The Journal of Experimental Biology·Guy A M MessaHans Degens

❮ Previous
Next ❯

Citations

May 4, 2021·Frontiers in Nutrition·Amy E MendhamNaomi E Brooks
Sep 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Olivia Di VincenzoLuca Scalfi
Jun 18, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ian C SmithWalter Herzog

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
electron microscopy
gastric bypass

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.