Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia

Frontiers in Medicine
Narong KhuntikeoPaiboon Sithithaworn

Abstract

Similar to bile duct cancer or cholangiocarcinoma (CCA) in the western world, opisthorchiasis-associated CCA in Southeast Asia is an aggressive cancer with high mortality rates. It is known to cause a significant health burden in the opisthorchiasis region in Thailand and possibly throughout mainland Southeast. To reduce this health burden, a comprehensive prevention and control program for opisthorchiasis, as well as CCA, is required. In this review, our aim is to provide a brief update of the current situation regarding the natural history of opisthorchiasis and health burden of CCA in Southeast Asia. A comprehensive approach to tackling these issues being implemented in Thailand under the "Cholangiocarcinoma Screening and Care Program" is described. This comprehensive program consists of a three stage prevention and patient care program. The primary prevention component involves opisthorchiasis screening using a new and sensitive urine assay. The secondary prevention component involves screening for CCA and periductal fibrosis, with suspected CCA patients following the protocol for confirmation and appropriate treatment. Due to the eco-epidemiology of opisthorchiasis-induced CCA, the anticipated impacts and outcomes of the p...Continue Reading

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Citations

Aug 1, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Chanika WorasithPaiboon Sithithaworn
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Aug 9, 2021·Acta Tropica·Oranard WattanawongBanchob Sripa

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Methods Mentioned

BETA
PCR
PCRs
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

CASCAP
CACAP
CASCAP Cloud

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