Current pharmacological approaches to the treatment of tendinopathy

Expert Opinion on Pharmacotherapy
Rocco AicaleN Maffulli

Abstract

Tendinopathies are common in elite and recreational athletes: traditionally considered overuse injuries, they involve excessive tensile loading and subsequent breakdown of the loaded tendon. Many pharmacological treatments have been proposed for the management of tendinopathy, with no agreement regarding the overall best option available both for Achilles and patellar tendinopathy. The present article reports the best scientific evidence regarding the efficacy and safety of different pharmacological treatments in different types of tendinopathy, focusing on Achilles and patellar tendinopathy, the conditions on which more studies have been published. No univocal evidence exists regarding the best non-operative management, which includes non-steroidal anti-inflammatory drugs, platelet-rich plasma, high volume image-guided injections, hyaluronic acid, and prolotherapy, for tendinopathy (in particular Achilles and patellar tendinopathies) as a suitable alternative to the commonly used eccentric loading rehabilitation regimen. It is unclear whether the combination of pharmacological substances with physical therapy would produce better results than physical therapy alone. There is an overall lack of published well-performed randomiz...Continue Reading

References

Dec 1, 1992·Acta Orthopaedica Scandinavica·M Aström, N Westlin
Mar 1, 1986·Sports Medicine·J G Williams
Sep 1, 1994·British Journal of Sports Medicine·P K KorkiaN Maffulli
Nov 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J A HannafinP A Torzilli
Oct 1, 1996·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·I ShrierH W Kohl
Jan 1, 1997·The American Journal of Sports Medicine·J J SoldatisJ H Wilber
Aug 26, 1998·Medicine and Science in Sports and Exercise·L C Almekinders, J D Temple
Dec 16, 1998·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·N MaffulliG Puddu
Jun 15, 1999·Osteoarthritis and Cartilage·K Yasuda, K Hayashi
Dec 2, 2000·The American Journal of Sports Medicine·N MaffulliS W Ewen
Apr 27, 2001·Medicine and Science in Sports and Exercise·F BenazzoN Maffulli
Jun 14, 2001·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·D MacAuley
Feb 20, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Graham P RileyRuud A Bank
Jul 30, 2002·British Journal of Sports Medicine·D KaderN Maffulli
May 1, 2004·The Journal of Bone and Joint Surgery. American Volume·Justin A PaoloniGeorge A C Murrell
Oct 2, 2004·Journal of the Royal Society of Medicine·Nicola MaffulliKaren L Luscombe
Jan 18, 2005·Sports Medicine·Koen H E Peers, Roeland J J Lysens
Feb 3, 2005·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Håkan Alfredson, Lars Ohberg
Feb 22, 2005·The American Journal of Sports Medicine·Oystein B LianRoald Bahr
Apr 14, 2005·Archives of Physical Medicine and Rehabilitation·Gastón Andrés TopolKhatab Mohammed Hassanein
Oct 26, 2005·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·P Sharma, N Maffulli
Jul 11, 2006·Journal of Science and Medicine in Sport·Murali K Sayana, Nicola Maffulli
Jul 13, 2006·The American Journal of Sports Medicine·Aasne HoksrudRoald Bahr
Aug 12, 2006·The American Journal of Sports Medicine·Bjarki Thor HaraldssonS Peter Magnusson
Aug 18, 2006·Journal of Science and Medicine in Sport·Nicholas J Rukin, Nicola Maffulli
Sep 13, 2006·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Bengt LindHåkan Alfredson
Mar 17, 2007·Connective Tissue Research·Wen-Chung TsaiJong-Hwei S Pang
May 8, 2007·The Journal of Hand Surgery·Gil S KrygerJames Chang
Sep 18, 2007·Journal of Science and Medicine in Sport·Merzesh Magra, Nicola Maffulli
Sep 21, 2007·Foot & Ankle International·Carol Frey, James Zamora
Mar 25, 2008·The American Journal of Sports Medicine·Timothy P C KaneJames D F Calder
May 13, 2008·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Michael ScarponeEdward Snell
Jul 9, 2008·Disability and Rehabilitation·Jan D RompeNicola Maffulli
Jul 9, 2008·Disability and Rehabilitation·Umile Giuseppe LongoNicola Maffulli
Jul 18, 2008·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Lotta WillbergHåkan Alfredson
Jan 7, 2009·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Robert A MagnussenA Brian Thomson

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Citations

Jan 9, 2021·Nature Reviews. Disease Primers·Neal L MillarScott A Rodeo
Mar 21, 2021·Journal of Orthopaedic Surgery and Research·Murat GurgerOnur Bingollu
Aug 17, 2021·Stem Cells Translational Medicine·Angela Palumbo PiccionelloMichele Riccio
Aug 29, 2021·International Journal of Pharmaceutics·Ayesha YounasNan Zhang

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