Current practice of diagnosis and reporting of prostate cancer on needle biopsy among genitourinary pathologists

Human Pathology
L EgevadJ I Epstein

Abstract

As there is a lack of hard data in the literature about many of the issues relating to diagnosing and reporting prostate cancer, we sought to survey current practices. A questionnaire was sent to 93 genitourinary pathologists with a response rate of 69%. Almost all respondents (95%) used formalin as fixative for needle biopsies. Unstained intervening sections were retained by 47%. Three levels of needle biopsies were used routinely by 63%. For verification of a diagnosis of cancer, high-molecular-weight cytokeratin was still the most commonly used immunohistochemical marker (91%), followed by p63 (58%) and alpha-methylacyl-CoA-racemase (50%). Features considered pathognomonic for cancer were glomeruloid bodies (58%), collagenous micronodules (64%), circumferential perineural invasion (84%), and growth in fat (36%). With none of these present, 39% required a minimum of 2 to 10 glands (median, 3) to diagnose cancer, whereas the others had no lower limit. A Gleason score was always given to even minute cancer foci by 86% and typically a Gleason score 6 was assigned (77%). Perineural invasion was mentioned by 86%. The extent of cancer on needle biopsies was quantified by all respondents with number of involved cores (80%) being the...Continue Reading

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Citations

Mar 24, 2007·BJU International·Sarah C FluryDan Theodorescu
Dec 3, 2008·Virchows Archiv : an International Journal of Pathology·Jonathan I Epstein
Jun 1, 2012·Scandinavian Journal of Urology and Nephrology·Stefan CarlssonLars Egevad
Oct 30, 2014·The American Journal of Surgical Pathology·Javier A Arias-StellaSean R Williamson
Jul 23, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Ersin KonyaliogluFerruh Zorlu
Dec 20, 2008·American Journal of Clinical Pathology·Peter A Humphrey
Sep 19, 2007·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Snezana CerovićVinka Maletić-Vukotić
Jan 9, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jacqueline FontugneScott A Tomlins
Jun 15, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sonja ChenAndres Matoso
Jan 7, 2020·Archives of Pathology & Laboratory Medicine·Esther I VerhoefGeert J L H van Leenders
Jan 4, 2012·Histopathology·Glen Kristiansen
Sep 21, 2007·Journal of Cellular Biochemistry·Chiara Grisanzio, Sabina Signoretti
Aug 3, 2017·Archives of Pathology & Laboratory Medicine·Francesca Khani, Brian D Robinson
Jan 7, 2021·Virchows Archiv : an International Journal of Pathology·Min LuChin-Lee Wu
Apr 15, 2006·Human Pathology·Brett Delahunt
Dec 25, 2007·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·Michel SouliéArnauld Villers
Dec 23, 2009·Pathology·Ana Richelia Jara-LazaroPuay Hoon Tan
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