Current prescription of prophylactic factor infusions and perceived adherence for children and adolescents with haemophilia: a survey of haemophilia healthcare professionals in the United States

Haemophilia : the Official Journal of the World Federation of Hemophilia
C D ThornburgC Leissinger

Abstract

The primary goal of prophylaxis in patients with severe haemophilia is to convert the phenotype from severe to moderate and to prevent the development of chronic arthropathy. Prior studies have demonstrated that prophylaxis decreases episodes of joint bleeds and chronic arthropathy. Effectiveness depends on prescription of prophylaxis and adherence to the prescribed regimen. The aim of this study was to determine if prescription of prophylaxis for children with haemophilia and perceptions of adherence to prophylaxis have changed since publication of the Joint Outcome Study (JOS). A questionnaire was sent, in electronic and written formats, to health professionals who provide care to children with haemophilia at US haemophilia treatment centres (HTCs). The response rate was 56 of 128 (44%) of the targeted HTCs. There were a few missing data and denominators are provided. All responses agreed with the results of the JOS and 30/55 (55%) reported the JOS increased their prescription of prophylaxis. Nineteen of 56 (34%) physicians or HTC staff reported that they had not prescribed prophylaxis within the last year due to concerns about adherence, and 19/56 (34%) reported they had stopped prophylaxis due to concerns about adherence wi...Continue Reading

References

Jul 1, 1992·Journal of Internal Medicine·I M NilssonH Pettersson
Mar 23, 1990·JAMA : the Journal of the American Medical Association·B M PsatyT S Inui
Nov 2, 2002·Haemophilia : the Official Journal of the World Federation of Hemophilia·K FischerH M van den Berg
Apr 16, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·J PanickerJ M Lusher
Apr 16, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·C T KiskerUNKNOWN Mononine Study Group
Apr 24, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·H M van den BergJ G van der Bom
Jun 28, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·K Fischer, M Van Den Berg
Sep 27, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·Regina B ButlerKaren Wulff
Aug 5, 2005·The New England Journal of Medicine·Lars Osterberg, Terrence Blaschke
Nov 4, 2005·The New England Journal of Medicine·Ronald J Campbell
Jan 18, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·K LindvallH Thykjaer
May 19, 2006·Journal of Thrombosis and Haemostasis : JTH·B M FeldmanUNKNOWN Association of Hemophilia Clinic Directors of Canada Prophylaxis Study Group
Aug 10, 2007·The New England Journal of Medicine·Marilyn J Manco-JohnsonBruce L Evatt
Sep 21, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·M RichardsC Rothschild
Sep 21, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·S du TreilC A Leissinger
Jun 25, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·K FischerV Blanchette
Jun 6, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·C E Walsh, L A Valentino
Nov 3, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·K KurnikG Auerswald
Nov 21, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·N DuncanA Shapiro
Jan 25, 2011·Journal of Thrombosis and Haemostasis : JTH·A GringeriUNKNOWN ESPRIT Study Group
Feb 24, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·A K C ChanM Warner
May 5, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·M V RagniC M Kessler
Sep 3, 2011·American Heart Journal·Hayden B BosworthChristopher B Granger

❮ Previous
Next ❯

Citations

May 27, 2015·Haemophilia : the Official Journal of the World Federation of Hemophilia·C M Witmer
Jan 3, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·L H SchrijversK Fischer
Jun 12, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·M J Manco-JohnsonUNKNOWN TEEN/TWEN Study Group
Apr 26, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·A Srivastava
Apr 12, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·S TealJ C Cappelleri
Nov 8, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·D NugentA Iorio
Jun 30, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·W Miesbach, W Kalnins
Jul 20, 2019·Haemophilia : the Official Journal of the World Federation of Hemophilia·Vanessa Giroto GuedesEdison Iglesias de Oliveira Vidal
Aug 13, 2013·International Journal of Clinical Pharmacy·Lorena Rocha AyresLeonardo Régis Leira Pereira
Aug 11, 2020·Pediatric Blood & Cancer·Johannes OldenburgGallia G Levy
Apr 11, 2018·BMJ Paediatrics Open·Nicola Rachel HusainStephen Tomlin
Jun 17, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Maria Elisa MancusoElena Santagostino
Sep 20, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·S BonanadE Brohan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Haemophilia : the Official Journal of the World Federation of Hemophilia
C E Walsh, L A Valentino
Haemophilia : the Official Journal of the World Federation of Hemophilia
P De MoerlooseM Richards
Haemophilia : the Official Journal of the World Federation of Hemophilia
N DuncanA D Shapiro
Journal of Thrombosis and Haemostasis : JTH
L M Aledort
© 2022 Meta ULC. All rights reserved