Current Progress and Challenges for Skeletal Muscle Differentiation from Human Pluripotent Stem Cells Using Transgene-Free Approaches

Stem Cells International
Nunnapas JiwlawatMasatoshi Suzuki

Abstract

Neuromuscular diseases are caused by functional defects of skeletal muscles, directly via muscle pathology or indirectly via disruption of the nervous system. Extensive studies have been performed to improve the outcomes of therapies; however, effective treatment strategies have not been fully established for any major neuromuscular disease. Human pluripotent stem cells have a great capacity to differentiate into myogenic progenitors and skeletal myocytes for use in treating and modeling neuromuscular diseases. Recent advances have allowed the creation of patient-derived stem cells, which can be used as a unique platform for comprehensive study of disease mechanisms, in vitro drug screening, and potential new cell-based therapies. In the last decade, a number of methods have been developed to derive skeletal muscle cells from human pluripotent stem cells. By controlling the process of myogenesis using transcription factors and signaling molecules, human pluripotent stem cells can be directed to differentiate into cell types observed during muscle development. In this review, we highlight signaling pathways relevant to the formation of muscle tissue during embryonic development. We then summarize current methods to differentiate...Continue Reading

References

May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T J BrennanE N Olson
Mar 1, 1991·The American Journal of Physiology·H H VandenburghR Feldstein
Sep 28, 1995·Nature·S JarriaultA Israel
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·O PourquiéN M Le Douarin
Oct 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Zhang, I S McLennan
Jul 2, 1999·Experimental Cell Research·K A ScataJ L Swain
Oct 19, 2006·Developmental Biology·Xuesong FengStephen H Devoto
Oct 25, 2006·The Journal of Cell Biology·Jacquelyn GerhartMindy George-Weinstein
Apr 10, 2007·Nature Medicine·Tiziano BarberiLorenz Studer
Aug 12, 2008·Cell·In-Hyun ParkGeorge Q Daley
Sep 26, 2008·The New England Journal of Medicine·Helen M Blau
Sep 9, 2009·Development·Renée van Amerongen, Roel Nusse
Oct 12, 2010·Stem Cells·Didier F PisaniClaude A Dechesne
May 17, 2011·Nature·Anne C RiosChristophe Marcelle
Sep 21, 2011·PloS One·Randi StewartRebecca Berdeaux
Feb 4, 2012·Cold Spring Harbor Perspectives in Biology·C Florian BentzingerMichael A Rudnicki
Aug 8, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Caroline BrunVéronique Blanquet
Jul 5, 2013·Organogenesis·Samad AhadianAli Khademhosseini
Dec 5, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Fabrizio Rinaldi, Rita C R Perlingeiro
Dec 11, 2013·Tissue Engineering. Part B, Reviews·Serge OstrovidovAli Khademhosseini
Dec 25, 2013·Annals of Biomedical Engineering·Swathi RangarajanNenad Bursac
Jan 8, 2014·Stem Cells Translational Medicine·Ramzey AbujarourPeter Flynn
Feb 12, 2014·Biomaterials Science·Xiufang GuoJames Hickman
Mar 25, 2014·Stem Cells Translational Medicine·Tohru HosoyamaMasatoshi Suzuki
May 2, 2014·Biochemical and Biophysical Research Communications·Tetsuhiko YasunoHidetoshi Kaneoka
May 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Gunnar SkoglundNacira Tabti
Nov 25, 2014·Journal of Cellular Physiology·Hongfang WangJon C Aster

❮ Previous
Next ❯

Citations

Apr 24, 2019·Small·Serge OstrovidovAli Khademhosseini
Jan 12, 2019·Journal of Clinical Pathology·Maria Ryssdal KrabyAnna M Bofin
May 8, 2020·The Journal of Biological Chemistry·Akihiko SakamotoKeiko Kashiwagi
Apr 8, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Elizabeth K BakerPeter G Davis
Aug 21, 2020·Disease Models & Mechanisms·Jeffrey W Santoso, Megan L McCain
Aug 16, 2019·International Journal of Molecular Sciences·Barbara Świerczek-LasekKarolina Archacka
Oct 12, 2020·Annals of the New York Academy of Sciences·María José Castellanos-MontielItzel Escobedo-Avila
Feb 17, 2021·Cellular and Molecular Life Sciences : CMLS·HoTae LimGabsang Lee
Apr 25, 2020·Stem Cell Reports·Jennifer B KwonCharles A Gersbach
Apr 2, 2021·BMC Biology·Hye In KaMin Jung Kim
Feb 27, 2021·Molecular Cancer Therapeutics·Korie A GraysonMichael R King
May 5, 2021·Seminars in Cell & Developmental Biology·Lu YanOlivier Pourquié
May 14, 2021·Journal of Animal Science and Biotechnology·Jinsol JeongChang-Kyu Lee
May 21, 2021·Journal for Immunotherapy of Cancer·Lingling OuXiaowei Xu
Jun 30, 2021·Journal of ISAKOS·Louis KluyskensDaniel B F Saris
Jul 25, 2021·International Journal of Molecular Sciences·Jacob ReissMasatoshi Suzuki
Aug 27, 2021·Advances in Pharmacological and Pharmaceutical Sciences·Janette A LindstromJean Sparks
Nov 16, 2021·Frontiers in Cell and Developmental Biology·Zachary FralishNenad Bursac

❮ Previous
Next ❯

Methods Mentioned

BETA
genetic modification
fluorescence-activated cell sorting
FCS
electron microscopy
FACS
SMA

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.