Current progress in the fatty acid metabolism in Cryptosporidium parvum

The Journal of Eukaryotic Microbiology
Guan Zhu

Abstract

Cryptosporidium parvum is one of the apicomplexans that can cause severe diarrhea in humans and animals. The slow development of anti-cryptosporidiosis chemotherapy is primarily due to the poor understanding on the basic metabolic pathways in this parasite. Many well-defined or promising drug targets found in other apicomplexans are either absent or highly divergent in C. parvum. The recently discovered apicoplast and its associated Type II fatty acid synthetic enzymes in Plasmodium, Toxoplasma, and Eimeria apicomplexans are absent in C. parvum, suggesting this parasite is unable to synthesize fatty acids de novo. However, C. parvum possesses a giant Type I fatty acid synthase (CpFAS1) that makes very long chain fatty acids using mediate or long chain fatty acids as precursors. Cryptosporidium also contains a Type I polyketide synthase (CpPKS1) that is probably involved in the production of unknown polyketide(s) from a fatty acid precursor. In addition to CpFAS1 and CpPKS1, a number of other enzymes involved in fatty acid metabolism have also been identified. These include a long chain fatty acyl elongase (LCE), a cytosolic acetyl-CoA carboxylase (ACCase), three acyl-CoA synthases (ACS), and an unusual "long-type" acyl-CoA bind...Continue Reading

References

Jan 1, 1993·Archives of Microbiology·N Arimura, T Kaneda
Aug 2, 1996·The Journal of Biological Chemistry·D A Toke, C E Martin
Nov 19, 1997·Natural Product Reports·B J Rawlings
Jun 20, 1998·Biochemical Pharmacology·C BaldockD W Rice
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·R F WallerG I McFadden
Nov 7, 1998·The Journal of Biological Chemistry·R J HeathC O Rock
Apr 10, 1999·The Journal of Biological Chemistry·R J HeathC O Rock
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·E ZutherP Gornicki
Feb 29, 2000·Molecular and Biochemical Parasitology·G ZhuJ S Keithly
Mar 9, 2000·Microbiology·G ZhuJ S Keithly
Aug 12, 2000·International Journal of Systematic and Evolutionary Microbiology·G ZhuH Philippe
Aug 16, 2000·Contributions to Microbiology·S Tzipori, G Widmer
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·J JelenskaP Gornicki
Jan 5, 2002·Progress in Lipid Research·Stephen Rawsthorne
Feb 13, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David S RoosBoris Striepen
Apr 12, 2002·International Journal for Parasitology·Pablo C Okhuysen, Cynthia L Chappell
May 31, 2002·The New England Journal of Medicine·Xian-Ming ChenNicholas F LaRusso
Jun 8, 2002·Journal of Molecular Biology·R J M Iain Wilson
Oct 9, 2002·Nature·Malcolm J GardnerBart Barrell
Dec 25, 2002·Antimicrobial Agents and Chemotherapy·Ross F WallerGeoffrey I McFadden
Feb 28, 2003·The Journal of Biological Chemistry·Mack R KuoDavid A Fidock
May 2, 2003·International Review of Cytology·Bernardo J Foth, Geoffrey I McFadden
Aug 9, 2003·International Journal for Parasitology·Piotr Gornicki
Aug 21, 2003·Current Genetics·Christina E RiordanJanet S Keithly
Jan 23, 2004·The Journal of Eukaryotic Microbiology·Leonardo CameroLihua Xiao
Feb 5, 2004·Bioorganic & Medicinal Chemistry·Simon M JonesIan H Gilbert

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Citations

Jan 10, 2008·Journal of Lipid Research·Cyrille BottéEric Maréchal
Sep 11, 2007·Eukaryotic Cell·Jason M FritzlerGuan Zhu
Jul 30, 2020·Biomolecules·Aleš TomčalaMiroslav Oborník
Aug 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jolly MazumdarBoris Striepen
Mar 11, 2005·Expert Opinion on Therapeutic Targets·Jochen Wiesner, Frank Seeber
Oct 10, 2006·IUBMB Life·Antonio D Uttaro
Feb 16, 2007·The Journal of Eukaryotic Microbiology·Marc A Toso, Charlotte K Omoto
Mar 17, 2007·Nature Reviews. Microbiology·Soo Hee LeePaul T Englund
Dec 20, 2011·The Journal of Biological Chemistry·Srinivasan RamakrishnanBoris Striepen
Aug 24, 2007·Eukaryotic Cell·Jolly Mazumdar, Boris Striepen
Mar 29, 2012·Parasitology Research·E Barbosa-CabreraR Campos-Rodríguez
Apr 1, 2014·Parasitology·Matthias Lendner, Arwid Daugschies
Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sebastian G GornikRoss F Waller
Jan 29, 2021·Frontiers in Microbiology·Xinyu YuJun Cao
Aug 3, 2021·Frontiers in Cellular and Infection Microbiology·Zahady D VelásquezAnja Taubert
Feb 4, 2009·Experimental Parasitology·Stanley Dean Rider, Guan Zhu

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Methods Mentioned

BETA
dissection
PCR

Software Mentioned

CpACS3

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