PMID: 8971470Nov 1, 1996Paper

Current progress in the gene therapy of cancer

Current Opinion in Oncology
B M DavisS L Gerson

Abstract

Gene transfer for the treatment of cancer is a rapidly expanding field. Recent studies can be divided into four main areas: 1) transfer of suicide genes that convert inactive prodrugs into cytotoxic compounds, 2) transfer of genes encoding cytokines and stimulatory markers to enhance immunogenicity against tumors, 3) transfer of tumor-suppressor genes to block tumor cell proliferation, and 4) transfer of drug resistance genes into hematopoietic stem cells to increase their resistance to myelo-suppressive chemotherapeutic agents. This review discusses recent advances in technique and knowledge and their application to the gene therapy of cancer.

Citations

Jan 19, 2000·Immunology Today·S LalP G Schlegel
Nov 4, 2000·Bioelectrochemistry·M BettanD Scherman
Oct 11, 2003·Biotechnology Advances·Sally McTaggart, Mohamed Al-Rubeai
May 5, 2001·Oral Oncology·T Sumida, H Hamakawa
Oct 16, 2001·Drugs & Aging·S Matzku, M Zöller
Oct 26, 1999·Immunobiology·M Zöller, S Matzku
Apr 16, 1998·The Journal of Investigative Dermatology·P A Khavari
Mar 24, 2018·The Journal of Chemical Physics·Vikramjit S RatheeJonathan K Whitmer

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