Current prospects and challenges of nanomedicine delivery in prostate cancer therapy

Nanomedicine
Santosh GuptaRama Shanker Verma

Abstract

Management of prostate cancer is currently being pursued by systemic delivery of anticancer drugs, but it has drawbacks like nonspecific distribution, decreased bioavailability, coupled with adverse side effects. These problems have been resolved using nanomedicine-based anticancer drug delivery to improve the therapeutic index with higher drug dose and reduced nonspecific distribution. Targeting prostate tumor by delivering nanomedicine through locoregional route is more effective, than the systemic delivery, which can decrease systemic exposure of the therapeutics significantly. Therefore, in this article, we have reviewed the current prospects and challenges of prostate cancer therapy using nanomedicine, by providing a comprehensive description of advantages and limitations of the systemic route and locoregional route. Eventually, we have emphasized on the need for localized prostate cancer therapy developments using nanomedicines.

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Citations

Feb 5, 2021·Advanced Drug Delivery Reviews·S G AntimisiarisS Mourtas
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Piyush Kumar GuptaDillip Kumar Bishi

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Methods Mentioned

BETA
xenograft
Fluorescence
imaging procedure
fluorescence microscopy
biopsies

Clinical Trials Mentioned

NCT02724618
NCT00689065
NCT00313599
NCT02341404
NCT00681148
NCT02654938
NCT00406939
NCT01310894

Software Mentioned

Transvas

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