Current questions in bone sarcomas

Current Opinion in Oncology
Sandra J Strauss, Jeremy S Whelan

Abstract

Osteosarcoma and Ewing sarcoma, the most common primary bone tumours in young people, are curable in most patients. However, these tumours remain a significant challenge due to the complexity and intensity of treatment and its long-term morbidity and the significant proportion of patients in whom treatment is unsuccessful. This review addresses questions about current management and emerging therapeutic targets for patients with osteosarcoma, Ewing sarcoma and chondrosarcoma, the commonest bone sarcoma but more common in older patients. The largest collaborative international study in osteosarcoma, EURAMOS-1 determined that treatment of patients with resectable disease should not be altered on basis of pathological response to neoadjuvant chemotherapy. In view of little improvement in outcome being evident in recent years, novel therapeutic approaches are required. Putative targets and clinical trials of novel agents are discussed, including emerging targets such as poly (ADP-ribose) polymerase inhibition and isocitrate dehydrogenase inhibition in Ewing sarcoma and chondrosarcoma, respectively. Newer radiotherapy techniques including proton beam and particle ion therapy may be important for local tumour control in selected pati...Continue Reading

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Citations

Jul 16, 2020·Skeletal Radiology·Ines OliveiraAsif Saifuddin
Apr 20, 2020·World Neurosurgery·Hongliang ZhangLin Wang
Aug 23, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Chuanxi ZhengChongqi Tu
Jan 1, 2022·Pediatric Blood & Cancer·Sharada MailankodyJyoti Bajpai

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Methods Mentioned

BETA
surgical resection
biopsy
exome sequencing

Clinical Trials Mentioned

NCT01330966

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