PMID: 6165867Jan 1, 1981

Current report on the interferon program at Roswell Park Memorial Institute

Journal of Surgical Oncology
G P Murphy


An overview of the interferon program at Roswell Park Memorial Institute (RPMI), is presented. This program encompasses three interrelated areas of research and new drug development: (a) basic research on purification and characterization of animal and human interferons (leukocyte, fibroblast, and immune); (b) large scale manufacture and preclinical testing of human fibroblast interferon (HFIF); and (c) clinical trials with HFIF to determine its safety of administration as well as antiviral, antitumor, and immunomodulatory activities in patients with neoplastic or viral disease. The antitumor effect of HFIF produced at RPMI as assessed by intralesional injection of various metastatic nodules resulted in an overall 71% local response. Phase I studies in 13 patients demonstrated that HFIF can be administered safely by the subcutaneous, intramuscular, and intravenous routes in doses up to 25 million units per day without any serious untoward effects. Intrathecal administration of HFIF into patients with CNS leukemia was also well tolerated. Pharmacokinetic studies indicated significant levels of HFIF in serum and cerebrospinal fluid after intravenous and intrathecal administration, respectively. Coincidental with the HFIF systemic...Continue Reading


Jan 1, 1979·Preparative Biochemistry·E Bollin, E Sulkowski
May 1, 1975·The Journal of Pediatrics·E De ClercqJ Desmyter
Jun 1, 1976·The Journal of Infectious Diseases·R SundmacherO Müller
Oct 1, 1978·Antimicrobial Agents and Chemotherapy·S B GreenbergR B Couch
Sep 18, 1977·Blut·H Strander
May 4, 1978·The New England Journal of Medicine·T C MeriganR P Fried
Dec 28, 1978·The New England Journal of Medicine·T C MeriganS A Rosenberg
Apr 5, 1979·Nature·M C Calvet, I Gresser
Jun 1, 1979·The Journal of General Virology·K C ChadhaE Sulkowski
Jan 10, 1978·Biochemistry·K C ChadhaW A Carter
Jan 1, 1976·Acta Medica Scandinavica·H BlomgrenH Strander
Sep 2, 1976·The New England Journal of Medicine·H B GreenbergT C Merigan
Jul 1, 1973·The Journal of General Virology·K Cantell, L Pyhälä
Dec 1, 1972·Antimicrobial Agents and Chemotherapy·E A Havell, J Vilcek
Jan 1, 1980·Pharmacology & Therapeutics·W A Carter, J S Horoszewicz


Jan 1, 1984·Neurosurgical Review·M Nagai, T Arai
Aug 1, 1992·International Journal for Parasitology·R B Kimsey
Dec 1, 1986·Journal of Surgical Oncology·L J Auguste, H Nava
Jan 1, 1984·The Prostate·J S Horoszewicz

Related Concepts

Drug Evaluation
Malignant Neoplasms

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.