PMID: 6165867Jan 1, 1981

Current report on the interferon program at Roswell Park Memorial Institute

Journal of Surgical Oncology
G P Murphy

Abstract

An overview of the interferon program at Roswell Park Memorial Institute (RPMI), is presented. This program encompasses three interrelated areas of research and new drug development: (a) basic research on purification and characterization of animal and human interferons (leukocyte, fibroblast, and immune); (b) large scale manufacture and preclinical testing of human fibroblast interferon (HFIF); and (c) clinical trials with HFIF to determine its safety of administration as well as antiviral, antitumor, and immunomodulatory activities in patients with neoplastic or viral disease. The antitumor effect of HFIF produced at RPMI as assessed by intralesional injection of various metastatic nodules resulted in an overall 71% local response. Phase I studies in 13 patients demonstrated that HFIF can be administered safely by the subcutaneous, intramuscular, and intravenous routes in doses up to 25 million units per day without any serious untoward effects. Intrathecal administration of HFIF into patients with CNS leukemia was also well tolerated. Pharmacokinetic studies indicated significant levels of HFIF in serum and cerebrospinal fluid after intravenous and intrathecal administration, respectively. Coincidental with the HFIF systemic...Continue Reading

References

Jan 1, 1979·Preparative Biochemistry·E Bollin, E Sulkowski
May 1, 1975·The Journal of Pediatrics·E De ClercqJ Desmyter
Jun 1, 1976·The Journal of Infectious Diseases·R SundmacherO Müller
Oct 1, 1978·Antimicrobial Agents and Chemotherapy·S B GreenbergR B Couch
Sep 18, 1977·Blut·H Strander
May 4, 1978·The New England Journal of Medicine·T C MeriganR P Fried
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Jun 1, 1979·The Journal of General Virology·K C ChadhaE Sulkowski
Jan 10, 1978·Biochemistry·K C ChadhaW A Carter
Jan 1, 1976·Acta Medica Scandinavica·H BlomgrenH Strander
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Jul 1, 1973·The Journal of General Virology·K Cantell, L Pyhälä
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Citations

Jan 1, 1984·Neurosurgical Review·M Nagai, T Arai
Aug 1, 1992·International Journal for Parasitology·R B Kimsey
Dec 1, 1986·Journal of Surgical Oncology·L J Auguste, H Nava
Jan 1, 1984·The Prostate·J S Horoszewicz

Related Concepts

Institutes
Drug Evaluation
Fibroblasts
Interferons
Malignant Neoplasms

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