Current research into novel therapeutic vaccines against cervical cancer

Expert Review of Anticancer Therapy
Marcelo Nazário CordeiroAntonio Carlos De Freitas

Abstract

Cervical cancer and cervical intraepithelial neoplasia (CIN) are well-known outcomes of a human papillomavirus (HPV) infection. Viral oncogenes expressions like E6, E7, and, recently recognized E5, lead to HPV-related malignant progression. Although HPV prevention by powerful vaccines against most frequent and oncogenic genotypes is feasible, current treatment against cervical neoplasia is distant from an ideal one. In addition, late diagnosis is commonly associated with a poor prognosis. On top of that, radiotherapy, chemotherapy, or surgery are less effective in high-grade lesions. Areas covered: Due to their peculiarities, HPV oncogenes represent an excellent target for cancer immunotherapy. Safety, efficacy, and potential immunogenicity are features achieved by DNA vaccines targeting HPV. The literature search has indicated that genetic immunotherapy is becoming a pharmacological tool and therapeutic option against cervical disease, as more and more DNA vaccines are reaching clinical trial phases. Expert commentary: Among some of the promising results, a phase II randomized trial showed a clinical activity of a nucleic acid-based vaccine in HPV16 or HPV18 positive CIN patients. The concept of a synergic combination of anti-...Continue Reading

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Citations

Apr 30, 2019·Frontiers in Plant Science·Silvia MassaAldo Venuti
Mar 27, 2020·Frontiers in Cell and Developmental Biology·Anh M TranGeorge A Calin
Sep 24, 2019·Human Vaccines & Immunotherapeutics· SunitaPratyoosh Shukla
Sep 12, 2019·Biochemistry. Biokhimii︠a︡·M S VonskyM G Isaguliants
Jul 17, 2019·La Presse médicale·Emilie BernichonNicolas Magné

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