Current role of autologous and allogeneic stem cell transplantation for relapsed and refractory hodgkin lymphoma

Mediterranean Journal of Hematology and Infectious Diseases
Luca CastagnaArmando Santoro

Abstract

Classical Hodgkin lymphoma (cHL) is a relatively rare disease, with approximately 9,200 estimated new cases and 1,200 estimated deaths per year in the United States. First-line chemo-radiotherapy leads to cure rates approaching 80% in patients with advanced-stage disease. However, 25 to 30% of these patients are not cured with chemotherapy alone (i.e., the ABVD regimen) and show either primary refractoriness to chemotherapy, early disease relapse or late disease relapse. Second-line salvage high-dose chemotherapy (HDC) and autologous stem cell transplantation (SCT) have an established role in the management of refractory/relapsed cHL, leading to durable responses in approximately 50% of relapsed patients and a minority of refractory patients. However, due to the poor responses to second-line salvage chemotherapy and dismal long-term disease control of primary refractory and early relapsed patients, their treatment represents an unmet medical need. Allogeneic SCT represents, by far, the only strategy with a curative potential for these patients; however, as discussed in this review, it's role in cHL remains controversial. Despite a general consensus that early relapsed and primary refractory patients represent a clinical challen...Continue Reading

Citations

Oct 22, 2016·Scientific Reports·Silvia Laura LocatelliCarmelo Carlo-Stella
Feb 16, 2019·British Journal of Haematology·Alessandra RomanoFrancesco Di Raimondo
Jul 29, 2016·Current Opinion in Oncology·Philippe Lewalle, Sebastian Wittnebel

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