Current scenario of indole derivatives with potential anti-drug-resistant cancer activity

European Journal of Medicinal Chemistry
Yanshu JiaXuefeng Wang

Abstract

Cancer chemotherapy is frequently hampered by drug resistance, so the resistance to anticancer agents represents one of the major obstacles for the effective cancer treatment. Indole derivatives have the potential to act on diverse targets in cancer cells and exhibit promising activity against drug-resistant cancers. Moreover, some indole-containing compounds such as Semaxanib, Sunitinib, Vinorelbine, and Vinblastine have already been applied in clinics for various kinds of cancer even drug-resistant cancer therapy. Thus, indole derivatives are one of significant resources for the development of novel anti-drug-resistant cancer agents. This review focuses on the recent development of indole derivatives with potential therapeutic application for drug-resistant cancers, and the mechanisms of action, the critical aspects of design as well as structure-activity relationships, covering articles published from 2010 to 2020.

Citations

Aug 14, 2020·Archiv der Pharmazie·Jue-Ying LiFeng-Xia Jiang
Sep 10, 2020·Current Topics in Medicinal Chemistry·Feng SongMeng Zhou
Oct 24, 2020·Current Topics in Medicinal Chemistry·Jiaqi XiaoFeng Gao

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