Current smoking and response to cholinesterase inhibitor therapy in Alzheimer's disease

Dementia and Geriatric Cognitive Disorders
P J Connelly, N P Prentice

Abstract

Current smoking has been suggested as predicting poor response to cholinesterase inhibitor treatment. This observational study compares response in subjects with NINCDS-ADRDA 'probable' Alzheimer's disease who are current smokers and subjects who are non-smokers. Smoking status was not associated with response. Smokers were significantly more likely to improve Digit Symbol Substitution Test (DSST) scores following treatment. In non-smokers, improvement from baseline DSST scores was associated with good response but this was not the case in smokers. The change in the DSST is in keeping with smokers having increased numbers of nicotinic receptors. In smokers, the lack of association between improvement in DSST scores and good response may be representative of inhibitory properties of cigarette smoke that are unrelated to nicotine.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Apr 16, 1986·Brain Research·P J WhitehouseK J Kellar
Aug 1, 1994·Psychopharmacology·D M Warburton, C Arnall
May 1, 1996·Neuron·J A Dani, S Heinemann
Apr 20, 2000·European Journal of Pharmacology·E D Levin, A H Rezvani
Apr 20, 2000·European Journal of Pharmacology·E PerryJ Court
Oct 18, 2002·Journal of the American Geriatrics Society·Li WangEric B Larson
Feb 7, 2003·International Journal of Geriatric Psychiatry·D P DevanandHarold A Sackeim
Apr 26, 2003·Neurobiology of Aging·Suzanne L TyasLenore J Launer

❮ Previous
Next ❯

Citations

Aug 3, 2007·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Jerome YesavageRuth O'Hara
Jul 16, 2005·International Journal of Geriatric Psychiatry·Peter J ConnellyKenneth G Fowler
Oct 7, 2019·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Kanika Arora, Divya Bhagianadh
Jul 7, 2005·International Journal of Geriatric Psychiatry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.