Current State of Circulating MicroRNAs as Cancer Biomarkers

Clinical Chemistry
Yuqing HeKai Wang

Abstract

Numerous studies have demonstrated the existence of stable regulatory RNAs, microRNAs (miRNAs), in the circulation and have shown that the spectrum of these extracellular miRNAs is affected by various pathologic conditions including cancers. Circulating miRNAs have been the focus of numerous cancer biomarker discovery efforts over the past few years; however, a considerable number of these studies have yielded inconsistent and irreproducible findings. Here, we have summarized and compared the results of studies covering 8 different cancer types to address key questions, including the possibility of using circulating miRNA to detect cancers and what factors may affect miRNA signatures. Although identifying circulating miRNA signatures to detect specific types of early stage cancers can be challenging, study results suggest that it may be possible to use miRNAs to detect cancers in general. Circulating miRNA is a rich source for potential disease biomarkers; however, factors, both intrinsic and extrinsic, that may affect measurement of circulating miRNA have not been fully characterized. Better understanding of intra- and intercellular miRNA trafficking and the fundamental biology of cancer cell-derived lipid vesicles may facilit...Continue Reading

References

Jan 11, 2008·Nature·Sohail F TavazoieJoan Massagué
Jan 26, 2008·Clinical Chemistry·Stephen S C ChimY M Dennis Lo
Jul 2, 2008·Molecular and Cellular Biology·Galina GabrielyAnna M Krichevsky
Jul 24, 2008·International Journal of Cancer. Journal International Du Cancer·Wenxi LiJianren Gu
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Feb 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kai WangDavid J Galas
Oct 31, 2009·International Journal of Cancer. Journal International Du Cancer·Zhaohui HuangXiang Du
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zhibin HuHongbing Shen
Mar 18, 2010·British Journal of Cancer·M TsujiuraE Otsuji
Apr 1, 2010·The Journal of Biological Chemistry·Nobuyoshi KosakaTakahiro Ochiya
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Jan C BraseHolger Sültmann
Jun 19, 2010·The American Journal of Pathology·Laura S DanielsonEva Hernando
Jul 10, 2010·Nucleic Acids Research·Kai WangDavid J Galas
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason D ArroyoMuneesh Tewari
Mar 16, 2011·Mutation Research·Alton EtheridgeKai Wang
Apr 14, 2011·Clinical Chemistry·Jennifer S McDonaldAlicia Algeciras-Schimnich
May 6, 2011·International Journal of Cancer. Journal International Du Cancer·Niels H H HeegaardCurtis C Harris
Jun 8, 2011·Nature Reviews. Clinical Oncology·Maria Angelica CortezGeorge A Calin
Jul 14, 2011·Journal of Hepatology·Yoshito TomimaruMasaki Mori
Sep 14, 2011·International Journal of Cancer. Journal International Du Cancer·Jianqiang LiuXiangyu Kong
Jan 13, 2012·Journal of Cancer Research and Clinical Oncology·Jinjin YuHaifeng Qiu
Feb 22, 2012·EMBO Molecular Medicine·Marilena V Iorio, Carlo M Croce
Aug 4, 2012·PloS One·Kai WangDavid J Galas
Aug 8, 2012·Annals of Surgery·Ziad KanaanSusan Galandiuk
Aug 22, 2012·The Journal of International Medical Research·F-L ZhaoZ-S Yu

❮ Previous
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Citations

Feb 24, 2016·Biosensors & Bioelectronics·Ana R CardosoM Goreti F Sales
Dec 20, 2015·Biochemical and Biophysical Research Communications·Xin HeChunjiang Yu
Feb 9, 2016·Expert Review of Molecular Diagnostics·Margaret Dellett, David Arthur Simpson
Mar 13, 2016·Journal of Gastrointestinal Cancer·Jian ZhouXin-Rong Yang
Apr 22, 2016·The Journal of Obstetrics and Gynaecology Research·Kohsuke KanekuraMasahiko Kuroda
May 9, 2016·The Journal of Allergy and Clinical Immunology·Chrysanthi SkevakiCatherine A Thornton
Jun 7, 2016·Biochimica Et Biophysica Acta·Subodh Kumar, P Hemachandra Reddy
Jun 28, 2016·Biomarkers in Medicine·Xiaoying JiangQilan Ning
Jul 4, 2016·Bulletin du cancer·Marc-Antoine BenderraChristophe Massard
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qin-Si Wan, Kun-He Zhang
Aug 17, 2016·Cancers·Tara SpenceFei-Fei Liu
Sep 3, 2016·Archives of Toxicology·Vikas Ghai, Kai Wang
Sep 10, 2016·Thyroid : Official Journal of the American Thyroid Association·Izumi HiratsukaMitsuyasu Itoh
Dec 6, 2016·Biomarkers in Medicine·Roberto Fiammengo
May 14, 2016·PloS One·Olivier SalaminNicolas Leuenberger
Dec 3, 2016·Nucleic Acids Research·Zhen YangAndrew E Teschendorff
Jun 25, 2016·PloS One·Jason Ioannidis, F Xavier Donadeu
Apr 8, 2017·PloS One·Shavahn C LouxBarry A Ball
Apr 28, 2017·Biomolecular Concepts·Virginie Armand-Labit, Anne Pradines
Dec 26, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Anton DobrinMartin Fussenegger
Jul 15, 2016·Reproductive Sciences·Lei WangXiaomeng Xia
Feb 7, 2018·International Journal of Molecular Sciences·Stefania TrinoLuciana De Luca
Mar 10, 2018·International Journal of Molecular Sciences·Yi-An ChangHsien-Da Huang
Nov 22, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Muller Fabbri
May 19, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ahmed Hussein ZedanPalle Jörn Sloth Osther
Jul 12, 2018·Journal of Cellular and Molecular Medicine·Juan LiYin-Yuan Mo
Jul 13, 2016·Annals of Human Genetics·Shenghui WuJun Dai
Jul 11, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·P W Ten BergJ W Dear
Aug 29, 2018·Chemical Communications : Chem Comm·Jiaoli WangKemin Wang
Nov 2, 2018·FEBS Letters·Yawei HanWei Hong
Apr 9, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Guo-Pan LiuAn-Quan Shang
Jun 5, 2019·Analytical and Bioanalytical Chemistry·Makoto KomoriToru Yoshimura

❮ Previous
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