Current state of immunotherapy for non-small cell lung cancer

Translational Lung Cancer Research
Jyoti MalhotraJoseph Aisner

Abstract

Lung cancer is the leading cause of cancer mortality and non-small cell lung cancer (NSCLC) accounts for more than 85% of all lung cancers. Platinum-based doublet chemotherapy is the standard first-line treatment for metastatic NSCLC when genomic testing reveals no targetable alteration such as epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) or ROS1 translocation/re-arrangements. But, chemotherapy produces response rates ranging only between 15-30%. For patients whose disease progresses on first-line chemotherapy, second-line therapy historically consists of taxane-based salvage chemotherapy with a response rate of less than 25%. Recently, immunotherapy with checkpoint inhibitor agents have demonstrated responses in advanced NSCLC, with some patients exhibiting durable responses after discontinuing therapy. In 2015, two immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), nivolumab and pembrolizumab were approved for second-line therapy of NSCLC. In 2016, another checkpoint inhibitor targeting program death-ligand 1 (PD-L1), atezolizumab was approved for the same indication. Moreover, pembrolizumab also received approval in 2016 for first-line NSCLC treatment in patients wit...Continue Reading

Citations

Oct 27, 2017·Expert Review of Molecular Diagnostics·Paul Hofman
Nov 30, 2019·Journal of Cellular and Molecular Medicine·Chenghan LuoYi Zhang
Mar 30, 2018·Clinical Chemistry·Vikram S Kumar
Aug 20, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Mesut Yilmaz, Sermin Guven Mese
Nov 7, 2019·International Journal of Molecular Sciences·Fabio PagniNicola Fusco
Jun 24, 2020·Cancers·Coral García-FernándezSalvador Borrós
Feb 20, 2019·Clinical Drug Investigation·Long LongHonglei Chen
May 29, 2020·Journal for Immunotherapy of Cancer·Fan SunZhaoxia Qu
Sep 15, 2018·Therapeutic Advances in Respiratory Disease·Nicolas Villanueva, Lyudmila Bazhenova
Sep 13, 2018·Journal of Oncology Practice·J Nicholas BodorHossein Borghaei
Dec 16, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Heng-Long WangJer-Yiing Houng
Aug 30, 2019·Experimental Hematology & Oncology·Zhenbin QiuWenzhao Zhong
Apr 12, 2019·Journal of Cancer Research and Clinical Oncology·Fabinshy ThangarajahAnne Maria Schultheis
May 29, 2020·Journal of Managed Care & Specialty Pharmacy·Nicole M Engel-NitzKellie J Ryan
Dec 24, 2018·International Journal of Molecular Sciences·Florian WirsdörferVerena Jendrossek
Jun 15, 2020·Oncogene·Stephanie R HyslopEmma C Josefsson
Aug 15, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sharon R Pine
Jan 13, 2021·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Nov 17, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Eileen McGowanYiguang Lin
Apr 24, 2021·Protein & Cell·Guang LeiBoyi Gan
May 1, 2021·Cancers·Kalyani B KarunakaranMadhavi K Ganapathiraju
May 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ze-Bo JiangElaine Lai-Han Leung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Journal of the National Comprehensive Cancer Network : JNCCN
Matthew A Gubens
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Amanda Rounds, Jill Kolesar
© 2022 Meta ULC. All rights reserved