Current state of transfusion practices for ABO-incompatible pediatric heart transplant patients in the United States and Canada

Transfusion
Christina L DeanCassandra D Josephson

Abstract

ABO compatibility restriction on solid organ transplantation limits organ availability. In an effort to increase organ availability, pediatric ABO-incompatible heart transplants (ABOiHT) are now performed with similar outcomes to ABO-compatible transplants. Transfusion support can be challenging and currently there are no standard guidelines for blood product support, ABO isohemagglutinin (IH) titer cutoffs for transplant eligibility, or therapeutic intervention for these patients. The study aim was to survey current blood bank and antibody reduction practices for pediatric ABOiHT in the United States and Canada. A Web-based survey was sent to 50 US and Canadian pediatric blood bank directors. Participants were queried regarding pre-, intra-, and postoperative blood product support; ABO IH titer testing; and antibody reduction practices in ABOiHT recipients. We analyzed 21 responses from US and Canadian centers that perform pediatric ABOiHT. There is wide variation in the type of blood products transfused and the modification of these products among respondents in the pre-, intra-, and postoperative settings. The frequency of testing ABO IH titers, implementing therapeutic intervention, and the type of therapeutic intervention ...Continue Reading

References

Mar 15, 2001·The New England Journal of Medicine·L J WestJ G Coles
Apr 10, 2004·Perfusion·C ForemanL West
Sep 16, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Michael SchmoeckelBruno Reichart
May 16, 2008·Vox Sanguinis·J P AuBuchonUNKNOWN Transfusion Medicine Resource Committee of the College of American Pathologists
Oct 18, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Nishant D PatelLuca A Vricella
Jan 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A I DipchandB W McCrindle
Feb 7, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Heather T HendersonKirk R Kanter
Jan 12, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Simon UrschelLori J West
Jun 24, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Simon UrschelLori J West
Jul 2, 2014·Annals of Laboratory Medicine·Seon Joo KangSae Yun Baik
May 28, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M JeyakanthanL J West
Jun 28, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Claire A IrvingRichard Kirk
Nov 26, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M JeyakanthanL J West
Jul 6, 2016·Current Opinion in Pediatrics·Simon Urschel, Lori J West
Sep 30, 2016·Archives of Pathology & Laboratory Medicine·Lohith S BachegowdaBeth H Shaz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
S L RocheA Hasan
Journal of Pediatric Hematology/oncology
Rachel S Bercovitz, Ralph R Quinones
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Heather T HendersonKirk R Kanter
© 2022 Meta ULC. All rights reserved