Current status and emerging challenges in the treatment of hepatitis C virus genotypes 4 to 6

World Journal of Clinical Cases
Vasilios Papastergiou, Stylianos Karatapanis

Abstract

Hepatitis C virus (HCV) genotypes 4, 5 and 6 are mainly present in Africa, the Middle East and Asia and they have been less extensively studied with respect to epidemiology, natural disease history and therapeutic endpoints. Response rates to a 48-wk combined peginterferon/ribavirin treatment range to 40%-69% for HCV 4, 55%-60% for HCV 5 and 60%-90% for HCV 6. Response-guided schedules are recommended to optimize the outcomes of peginterferon/ribavirin treatment in HCV 4 and, in form of preliminary data, for HCV 6, but no data are yet available to support such an individualization of therapy for HCV 5. Recently, the direct-acting antivirals (DAAs) with pan-genotypic activities simeprevir, sofosbuvir and daclatasvir have been recommended in triple regimens with peginterferon/ribavirin for the treatment of HCV genotypes 4 to 6 infections. In the future, DAA-based interferon-free therapies are awaited to drastically improve treatment outcomes in HCV. However, efforts to improve treatment outcomes with peginterferon/ribavirin should continue, as the HCV 4-6 infected population is mainly based in resource-limited settings with restricted access to the costly DAAs.

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Citations

Sep 12, 2015·Biochemical Pharmacology·Samar F DarwishEbtehal El-Demerdash
Nov 26, 2015·Gastroenterology Clinics of North America·Nghia H Nguyen, Mindie H Nguyen
Aug 16, 2016·Frontiers in Pharmacology·Winnie de BruijnBrian Godman
Jun 17, 2016·The Annals of Pharmacotherapy·José A Morales-MolinaAlba Martos-Rosa
Dec 17, 2015·World Journal of Hepatology·Tawhida Y Abdel-GhaffarSuzan El Naghi
Oct 20, 2015·World Journal of Gastroenterology : WJG·Simona Ruta, Costin Cernescu

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