Current status and future perspectives of in vivo small animal imaging using radiolabeled nanoparticles

European Journal of Radiology
George LoudosDimitris Psimadas

Abstract

Small animal molecular imaging is a rapidly expanding efficient tool to study biological processes non-invasively. The use of radiolabeled tracers provides non-destructive, imaging information, allowing time related phenomena to be repeatedly studied in a single animal. In the last decade there has been an enormous progress in related technologies and a number of dedicated imaging systems overcome the limitations that the size of small animal possesses. On the other hand, nanoparticles (NPs) gain increased interest, due to their unique properties, which make them perfect candidates for biological applications. Over the past 5 years the two fields seem to cross more and more often; radiolabeled NPs have been assessed in numerous pre-clinical studies that range from oncology, till HIV treatment. In this article the current status in the tools, applications and trends of radiolabeled NPs reviewed.

References

Sep 1, 1991·Neurochemical Research·M E Phelps
Nov 1, 1996·Chemistry & Biology·S Strömblad, D A Cheresh
May 22, 1998·Breast Cancer Research and Treatment·G De VincentisF Scopinaro
Oct 30, 1998·Biomaterials·T YamamuroY Senaha
Sep 11, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·W A WeberM Schwaiger
Jul 21, 2000·Current Pharmaceutical Design·M T Ercan, L Kostakoğlu
Apr 21, 2001·Bioconjugate Chemistry·R WeisslederH J Weinmann
Apr 27, 2001·Radiology·R Weissleder, U Mahmood
Jun 15, 2001·ILAR Journal·R S Balaban, V A Hampshire
Jan 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Arion F Chatziioannou
Jun 29, 2002·Science·John D HoodDavid A Cheresh
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Francis G Blankenberg, H William Strauss
Jan 8, 2003·Seminars in Oncology·Judah Folkman
Jun 5, 2003·Nature Medicine·Donald M McDonald, Peter L Choyke
Oct 28, 2003·European Journal of Nuclear Medicine and Molecular Imaging·John L HummAlberto Del Guerra
Mar 17, 2004·Biomaterials·T MatsumotoJ Takahashi
May 1, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Xiaoyuan ChenPeter S Conti
Aug 3, 2004·Physics in Medicine and Biology·Yong Hyun ChungByung-Tae Kim
Nov 27, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Lukas B BeenPhilip H Elsinga
Oct 29, 2005·Nuclear Medicine and Biology·Terry L SharpMichael J Welch
Nov 3, 2005·Physics in Medicine and Biology·Steven R MeikleRichard B Banati
Nov 30, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yutaka MizushimaAkinori Ueno
Dec 15, 2005·Proceedings of the American Thoracic Society·Arion F Chatziioannou
Feb 2, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Sandrine BallotJean-Pierre Benoit
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ravi SinghKostas Kostarelos
Mar 1, 2006·The Journal of Pharmacology and Experimental Therapeutics·Silvia MuroVladimir R Muzykantov
May 9, 2006·Respiration; International Review of Thoracic Diseases·Barbara M Fischer, Jann Mortensen
May 16, 2006·Zeitschrift für medizinische Physik·Habib Zaidi
Jul 11, 2006·Current Opinion in Chemical Biology·Shimon Gross, David Piwnica-Worms
Jan 24, 2007·Current Opinion in Biotechnology·Lawrence W Dobrucki, Albert J Sinusas
Feb 13, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Otilia M KooHayat Onyuksel
Apr 25, 2007·NMR in Biomedicine·Nicolau BeckmannMatthias Müller
May 10, 2007·Nature Protocols·Ganesan Vaidyanathan, Michael R Zalutsky
Aug 4, 2007·Journal of Digital Imaging·George C KagadisGeorge C Nikiforidis
Aug 21, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Meike L SchipperSanjiv S Gambhir
Sep 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Derek W BartlettMark E Davis
Oct 31, 2007·Journal of Drug Targeting·Eun-Mi KimMyung Hee Sohn

❮ Previous
Next ❯

Citations

Apr 19, 2011·Journal of Cell Communication and Signaling·Agata NygaMarilena Loizidou
Apr 11, 2012·Journal of Pharmaceutical Sciences·Dimitrios PsimadasGeorge Loudos
Dec 15, 2012·Nuclear Medicine and Biology·Irene TsiapaGeorge C Kagadis
Apr 25, 2013·Contrast Media & Molecular Imaging·Dimitrios PsimadasGeorge Loudos
Jul 22, 2014·Contrast Media & Molecular Imaging·José Carlos De La Vega, Urs O Häfeli
Feb 15, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·B I TambaA Tijani
Feb 8, 2013·Toxicologic Pathology·Ann F HubbsRobert R Mercer
Jan 26, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andreas SchmidMichael Schwarz
Aug 10, 2019·Applied Biochemistry and Biotechnology·Somayeh Akbari-KaradehSaeid Ghorbanzadeh-Mashkani
Jun 17, 2020·Chemical Society Reviews·Saeid KargozarMasoud Mozafari
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bianca Elena-Beatrice CrețuVera Balan
Jul 20, 2021·International Journal of Biological Macromolecules·Nourihan S FarragWael Mamdouh
Jan 20, 2021·ACS Biomaterials Science & Engineering·Teresa Martínez MartínezAntonio Abel Lozano-Pérez
Jan 17, 2012·Bioconjugate Chemistry·Yongjian Liu, Michael J Welch

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cancer Cell Invasion: Nanomedicine

Nanomedicine is a promising alternative for cancer detection and therapy that utilizes nanoparticles, such as liposomes. Nanoparticles can potentially target cancer cell invasion and metastasis. Discover the latest research on Cancer Cell Invasion: Nanomedicine here.