Current status and future perspectives of the PumpKIN trial

Translational Pediatrics
Iki Adachi

Abstract

Similar to the adult experience, the use of continuous-flow ventricular assist devices (VADs) has been increasing in the pediatric population. According to the PediMACS registry, continuous-flow VAD currently accounts for >60% of the durable device implantations in the U.S. Nonetheless, the continuous-flow VADs currently in use are designed for adults; this inevitably causes the patient-device size mismatch issue, especially when applied for small children. Pulsatile VADs, therefore, represent the only practical option for this group of patients despite the known risk profile of pulsatile VADs. To address such a frustrating reality, the National Heart, Lung, and Blood Institute (NHLBI) launched the Pediatric Circulatory Support Program in 2004, which is the predecessor of the so-called PumpKIN (Pump for Kids, Infants, and Neonates) program. The goal of this program was to develop mechanical circulatory support devices specifically designed for small children. As a result of extensive efforts of the multi-disciplinary team involving clinicians, scientists, manufactures, and federal agencies, the Infant Jarvik 2015, one of the original devices within the Pediatric Circulatory Support Program, has become the first continuous-flow ...Continue Reading

Citations

Apr 19, 2020·Current Opinion in Organ Transplantation·Zachary A SpigelIki Adachi
Oct 31, 2019·World Journal for Pediatric & Congenital Heart Surgery·Sebastian C TumeJenna Murray
May 29, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alexandra IdrovoAyse Akcan-Arikan
Jul 16, 2020·Heart, Lung & Circulation·Laura M DavisJohann Brink
Jun 24, 2021·Expert Review of Medical Devices·Louis MarcelSmaine Kouidri
Jul 2, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Angela LortsAntonio Amodeo
Jul 14, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J B EdelsonJ W Rossano
Aug 22, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Seth A HollanderUNKNOWN ACTION Network
Nov 24, 2021·Current Opinion in Anaesthesiology·Catherine S ReidMatthias Siepe

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