Current status and future prospects of array-based comparative genomic hybridisation

Briefings in Functional Genomics & Proteomics
Antoine M SnijdersDonna G Albertson

Abstract

The majority of human cancers as well as many developmental abnormalities harbour chromosomal imbalances, many of which result in the gain and/or loss of genomic material. Conventional comparative genomic hybridisation (CGH) has been used extensively to map DNA copy number changes to chromosomal positions. The introduction of microarray CGH provided a powerful tool to precisely detect and quantify genomic aberrations and map these directly onto the sequence of the human genome. In the past several years, a number of different approaches towards array-based CGH have been undertaken. This paper reviews these approaches and presents some of the recently-developed applications of this new technology in both research and clinical settings.

Citations

Sep 24, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Verena L BauerHorst F Zitzelsberger
Apr 23, 2005·Bioinformatics·Qunhua LiAdrian E Raftery
Dec 17, 2008·Yi chuan = Hereditas·Yuan-Bo Xue, Xin Song
Mar 28, 2007·Heart Failure Clinics·Neil E BowlesJeffrey A Towbin
Mar 10, 2005·American Journal of Human Genetics·Pawandeep DhamiDavid Vetrie
Dec 6, 2005·Pathology, Research and Practice·Jorge S Reis-FilhoSunil R Lakhani
Aug 12, 2010·Molecular Cancer·Lynda Addou-KloucheMax Chaffanet
Jan 8, 2015·Cellular Oncology (Dordrecht)·Mohammad ShahjahaniNajmaldin Saki
Nov 17, 2005·European Journal of Human Genetics : EJHG·William W LockwoodWan L Lam
Jul 20, 2006·Journal of Neuro-oncology·Andrey KorshunovRegina Sycheva
Feb 9, 2005·Molecular Psychiatry·J L RapoportM R C Psych
Aug 30, 2007·European Journal of Human Genetics : EJHG·Sarah T SouthArthur R Brothman
May 2, 2007·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Margarete OdenthalLudwig Eichinger
Apr 25, 2007·Critical Reviews in Toxicology·Om P SharmaPritam D Sharma
Jan 13, 2005·Environmental and Molecular Mutagenesis·R Julian Preston

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