Current status and perspective of angiogenesis and antivascular therapeutic strategy: non-small cell lung cancer.

International Journal of Clinical Oncology
Seiji YanoSaburo Sone

Abstract

Lung cancer is the leading cause of cancer death worldwide, and most patients die of metastatic disease. Angiogenesis, namely, neovascularization from preexisting vasculature, is necessary for tumor growth in both primary and distant organs to supply oxygen and nutrition. Angiogenesis consists of sprouting and nonsprouting (the enlargement, splitting, and fusion of preexisting vessels) processes, and both can occur concurrently. The growth of non-small cell lung cancer (NSCLC), which accounts for more than 80% of all lung cancers, is usually dependent on angiogenesis, which is regulated by complex mechanisms in the presence of various angiogenesis-related molecules. Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is one of the most potent angiogenic molecules, while also regulating both angiogenesis and vascular permeability and hence promoting tumor progression and the development of malignant pleural effusions in NSCLC. Recent clinical trials showed that the anti-VEGF antibody bevacizumab, combined with standard first-line chemotherapy, provided a statistically and clinically significant survival advantage with tolerable toxicity. In addition, the combined use of the anti-VEGF anti...Continue Reading

References

Aug 12, 1971·The New England Journal of Medicine·J Folkman
Jul 17, 1996·International Journal of Cancer. Journal International Du Cancer·S YanoS Sone
Jun 18, 1997·Journal of the National Cancer Institute·G FontaniniG Bevilacqua
Sep 29, 1999·Cancer Immunology, Immunotherapy : CII·H YanagawaS Sone
Apr 6, 2000·Journal of the National Cancer Institute·J Randal
Feb 15, 2001·Nature Medicine·K Plate
Feb 27, 2001·The British Journal of Ophthalmology·U Pleyer
Mar 22, 2002·The Lancet Oncology·Isaiah J FidlerCorazon D Bucana
Sep 14, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstJames L Abbruzzese
Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harold F Dvorak
May 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Masahiro FukuokaJosé Baselga
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David H JohnsonFairooz Kabbinavar
Aug 5, 2004·Journal of the National Cancer Institute·Federico CappuzzoLucio Crinò
Oct 22, 2004·Human Molecular Genetics·Soji KakiuchiYusuke Nakamura
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hisatsugu GotoSaburo Sone
Dec 2, 2004·Nature Reviews. Cancer·Roy S HerbstJosé Baselga
Dec 23, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dirk StrumbergSiegfried Seeber
May 5, 2005·Journal of the National Cancer Institute·Federico CappuzzoMarileila Varella-Garcia
May 12, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstAlan Sandler
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cheng-Long HuangMasaki Ueno
Dec 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Seiji YanoSaburo Sone
Jan 13, 2006·The Oncologist·Ornella Belvedere, Francesco Grossi

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Citations

Oct 19, 2006·Respiratory Research·Andriana I PapaioannouKonstantinos I Gourgoulianis
May 17, 2007·Chest·Joo Hun ParkSung Chul Hwang
Nov 4, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yiguang WangQiang Zhang
Jun 6, 2009·The American Journal of Pathology·Tomoko HosakaYasufumi Sato
Sep 2, 2008·Seminars in Arthritis and Rheumatism·Qingping YaoErnest Brahn
Oct 24, 2007·Life Sciences·Subir Kumar Das, D M Vasudevan
Mar 8, 2012·Toxicology Mechanisms and Methods·Subir Kumar DasD M Vasudevan
May 16, 2012·Respiration; International Review of Thoracic Diseases·Marios E Froudarakis
Nov 18, 2010·Organic & Biomolecular Chemistry·David J EdwardsSylvie Ducki
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hirokazu OginoSaburo Sone
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James E Talmadge
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tom DonnemRoy M Bremnes

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