Current status and perspectives of patient-derived xenograft models in cancer research

Journal of Hematology & Oncology
Yunxin LaiPeng Li

Abstract

Cancers remain a major public health problem worldwide, which still require profound research in both the basic and preclinical fields. Patient-derived xenograft (PDX) models are created when cancerous cells or tissues from patients' primary tumors are implanted into immunodeficient mice to simulate human tumor biology in vivo, which have been extensively used in cancer research. The routes of implantation appeared to affect the outcome of PDX research, and there has been increasing applications of patient-derived orthotopic xenograft (PDOX) models. In this review, we firstly summarize the methodology to establish PDX models and then go over recent application and function of PDX models in basic cancer research on the areas of cancer characterization, initiation, proliferation, metastasis, and tumor microenvironment and in preclinical explorations of anti-cancer targets, drugs, and therapeutic strategies and finally give our perspectives on the future prospects of PDX models.

References

Jul 30, 1992·International Journal of Cancer. Journal International Du Cancer·P WangE Klein
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·X FuR M Hoffman
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Mar 16, 2005·Cancer Cell·Kiranmai GumireddyE Premkumar Reddy
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leonard D ShultzRupert Handgretinger
May 17, 2005·Cancer Cell·Janet PlesciaDario C Altieri
Nov 8, 2005·Nature·David B SolitNeal Rosen
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Belen Rubio-ViqueiraManuel Hidalgo
Apr 5, 2007·Nature Protocols·Christopher L Morton, Peter J Houghton
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elisabetta MarangoniMarie-France Poupon
Sep 6, 2007·Cancer Cell·Jialiang WangWendell G Yarbrough
Aug 9, 2008·International Journal of Cancer. Journal International Du Cancer·Alice AglianoFrancesco Bertolini
Jun 9, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Johannes MerkIduna Fichtner
Oct 6, 2009·Cancer Cell·Cynthia K HahnKimberly Stegmaier
Jan 29, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rebekka KrumbachThomas Beckers
Mar 20, 2012·Cellular & Molecular Immunology·Adam C DrakeJianzhu Chen
Apr 18, 2012·Nature Reviews. Clinical Oncology·John J TentlerS Gail Eckhardt

❮ Previous
Next ❯

Citations

Feb 22, 2018·Cancers·Pujan Kandel, Michael B Wallace
Apr 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monika ŚwierczewskaRadosław Januchowski
Sep 15, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jaeyun JungSuhwan Chang
Dec 5, 2018·Expert Opinion on Drug Discovery·Anuradha Roy
Dec 13, 2018·ILAR Journal·Jason S VillanoPatrick A Lester
Feb 13, 2019·Cells·Karl Roland EhrenbergClaudia R Ball
Feb 28, 2018·Journal of Experimental & Clinical Cancer Research : CR·Y T LuoQ Huang
Feb 28, 2019·Journal of Gastroenterology·Pujan Kandel, Michael B Wallace
Mar 24, 2018·Future Science OA·Erica YadaTetsuro Sasada
May 6, 2019·ILAR Journal·Sue E KnoblaughKrista M D La Perle
Sep 17, 2018·Journal of Hematology & Oncology·Hanxiao XuKongming Wu
Jan 18, 2018·Expert Opinion on Drug Discovery·Elizabeth Magnotti, Wayne A Marasco
Nov 15, 2019·FEBS Letters·José Gabriel Barcia DuránShahin Rafii
Nov 15, 2019·Small·Kirsten Lee FetahNureddin Ashammakhi
Dec 28, 2019·Advanced Materials·María Virtudes CéspedesAntonio Villaverde
Feb 23, 2020·Drug Metabolism Reviews·Neha MaharaoJyotika Varshney
Mar 4, 2020·Oncogene·Melissa M WolfKathryn E Beckermann
Jun 2, 2018·Oncotarget·Laura L StafmanElizabeth A Beierle
Apr 11, 2020·Molecular Carcinogenesis·J Jason MortonAntonio Jimeno
Jun 25, 2020·Japanese Journal of Clinical Oncology·Yanmei ZhangWei Xu
May 7, 2020·JCO Clinical Cancer Informatics·Rupam BhattacharyyaVeerabhadran Baladandayuthapani
Mar 29, 2018·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Anja Kathrin Wege
Jul 16, 2020·Gastroenterology Report·Mengjun Zhong, Liwu Fu
Mar 1, 2019·Journal of Translational Medicine·Hélios BertinFrançoise Rédini
Mar 6, 2019·Therapeutic Advances in Medical Oncology·Rafael CaparicaMartine Piccart
Jul 31, 2020·British Journal of Cancer·Ross J PorterMairi H McLean
Oct 17, 2018·Frontiers in Immunology·Huensuk Kim, Christoph Schaniel

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
xenografts
fluorescence-activated cell sorting
single-cell sequencing

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.