PMID: 374890Feb 1, 1979Paper

Current status of age altered enzymes: alternative mechanisms

Mechanisms of Ageing and Development
D Gershon

Abstract

The occurrence of inactive enzyme molecules in a variety of tissues and animal species has been shown to be of a general nature. The levels of inactive enzyme molecules found in old animals were produced by amino acid analogs in young animals. These levels have been shown to be initially detrimental but subsequently the young system shows recovery by efficiently disposing of the analog-modified proteins. In old animals this disposal is considerably less efficient. Evidence is presented which suggests that post-translational modifications of proteins are the main cause of enzyme inactivation in old animals. Amino acid substitutions and modifications involving charge differences apparently do not contribute significantly to this phenomenon.

References

Apr 1, 1976·European Journal of Biochemistry·U Reiss, D Gershon
May 1, 1976·Archives of Biochemistry and Biophysics·S K Gupta, M Rothstein
Sep 1, 1975·Experimental Cell Research·J PithaE Wimmer
Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J D Etlinger, A L Goldberg
Jul 1, 1977·Mechanisms of Ageing and Development·M Rothstein
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·P Edelmann, J Gallant
May 1, 1976·Archives of Biochemistry and Biophysics·H K SharmaM Rothstein
Nov 22, 1976·Biochemical and Biophysical Research Communications·U Reiss, D Gershon
May 27, 1977·Biochimica Et Biophysica Acta·R J Truscott, R C Augusteyn
Sep 1, 1977·Mechanisms of Ageing and Development·A Z Reznick, D Gershon
Oct 11, 1976·Biochimica Et Biophysica Acta·S K Gupta, M Rothstein
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S LinnR Holliday
Jul 1, 1975·Archives of Biochemistry and Biophysics·R Bolla, N Brot
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H Gershon, D Gershon
Apr 1, 1973·Mechanisms of Ageing and Development·H Gershon, D Gershon
Oct 17, 1974·Biochimica Et Biophysica Acta·F Mennecier, J C Dreyfus
Dec 11, 1974·Biochemical and Biophysical Research Communications·U Reiss, M Rothstein
Sep 19, 1970·Nature·H Gershon, D Gershon
Apr 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·L E ORGEL

❮ Previous
Next ❯

Citations

Jan 1, 1987·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J ScharfD Gershon
Apr 5, 2000·Pathology Oncology Research : POR·R Ladislas
Jan 1, 1983·The International Journal of Biochemistry·A BartkowiakG Bartosz
Nov 1, 1979·Mechanisms of Ageing and Development·J Y Le GallA Guillouzo
Jan 1, 1980·Mechanisms of Ageing and Development·R B Burrows, P F Davison
Jan 1, 1980·Mechanisms of Ageing and Development·G Bartosz
Jan 1, 1981·Mechanisms of Ageing and Development·E Steinhagen-ThiessenH Hilz
Nov 1, 1981·Mechanisms of Ageing and Development·G BartoszW Retelewska
Sep 1, 1984·Mechanisms of Ageing and Development·N W Flodin
Aug 1, 1984·Mechanisms of Ageing and Development·A A Okada, J F Dice
Jul 1, 1984·Mechanisms of Ageing and Development·Y Sambuy, A H Bittles
Oct 1, 1988·Mechanisms of Ageing and Development·M Nakano, H Tauchi
Nov 24, 2001·Mechanisms of Ageing and Development·Alexey G Ryazanov, Bradley S Nefsky
Dec 18, 2001·Mechanisms of Ageing and Development·Harriet Gershon, David Gershon
Feb 13, 2001·Experimental Gerontology·A Globerson
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C B HarleyS Goldstein
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S M GartlerA G Motulsky
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A Z ReznickD Gershon
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K C Yuh, A Gafni
Dec 15, 1988·European Journal of Biochemistry·R Takahashi, S Goto
Aug 1, 1983·Biological Reviews of the Cambridge Philosophical Society·S C Makrides
Aug 1, 1990·Biological Reviews of the Cambridge Philosophical Society·Z A Medvedev
May 15, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jerrold Scott PetrofskyJoshua Andrade
Mar 25, 2004·Aging Cell·Richard A Miller
May 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J F Dice
May 1, 1980·Journal of Cellular Physiology·R I Wojtyk, S Goldstein
Jan 25, 2002·Annals of the New York Academy of Sciences·S GotoR Abe
May 25, 1983·Biochimica Et Biophysica Acta·A Dovrat, D Gershon
Mar 1, 1991·Mutation Research·R F Rosenberger
Jan 1, 1982·Experimental Gerontology·M Laughrea

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.