Abstract
During the past decade it has become apparent that patients can be transplanted successfully after preparation with regimens of reduced intensity. Reduced intensity preparations have resulted in lower morbidity and mortality during the pre-engraftment period, but have not reduced later occurring infections, GVHD and relapse. Outcome-determining risk factors that characterize patients at diagnosis as well as during their course include age, cytogenetic configuration, hematopoietic elements and a previous history of myelodysplasia or cytoreductive therapy for a pre-existing malignancy. These factors are complemented by the response to induction therapy and subsequent treatments as well as by the duration of the response. More recently, gene expression profiling of leukemic cells has added a new dimension to simultaneously assessed biological risk factors that may ultimately lead to individuation of therapy.
References
Sep 18, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yves ChalandonDonna E Hogge
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hartmut BertzJürgen Finke
Apr 26, 2003·Blood·Stefan SuciuUNKNOWN EORTC and GIMEMA Leukemia Groups
Dec 17, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·H C FungS J Forman
Jan 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dimitri A BreemsBob Löwenberg
Mar 3, 2005·Cancer·Masamitsu YanadaTomoki Naoe
May 4, 2005·Blood·Alexandros SpyridonidisJürgen Finke
Mar 1, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gordon CookDavid I Marks
Mar 21, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·David I MarksMary M Horowitz
Mar 21, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Asha JohnyThomas J Nevill
Jan 16, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Brenda M SandmaierRichard W Childs
Mar 22, 2007·Blood·Martin S TallmanDaniel J Weisdorf
Apr 26, 2007·Blood·Adam J MeadRosemary E Gale
May 10, 2007·British Journal of Haematology·Claudia D BaldusClara D Bloomfield
May 29, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Philippe ArmandRobert J Soiffer
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guido MarcucciUNKNOWN Cancer and Leukemia Group B Study
Jun 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·James A RussellDouglas A Stewart
Jun 28, 2007·Blood·Christoph KahlRainer Storb
Jul 6, 2007·Leukemia·B OranM de Lima
Oct 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christoph SchmidUNKNOWN EBMT Acute Leukemia Working Party
Citations
Mar 2, 2011·Bone Marrow Transplantation·C SchmidH-J Kolb
Apr 27, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mohamed A Kharfan-DabajaMehdi Hamadani
Jan 25, 2008·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·L SándorP Elek