Current status of clinical studies for colorectal cancer in Taiwan

Clinical Colorectal Cancer
Li-Tzong Chen, Jacqueline Whang-Peng

Abstract

The incidence and age-adjusted mortality of colorectal cancer (CRC) has drastically increased in the past 2 decades in Taiwan. Fortunately, chemotherapy for metastatic CRC also showed improvement in terms of tumor response rate and survival in the corresponding time period. For its low toxicity profile and high objective response rate (17.5%-31.9% in patients who received low-dose 5-fluorouracil [5-FU] that failed and 53.3%-61.5% in patients who were chemotherapy-naive), weekly 24-hour infusion of high-dose 5-FU and leucovorin (LV) has been a favorable regimen for advanced CRC for medical oncologists in Taiwan. Investigators also put their effort in exploring the mechanisms of high efficacy and low toxicity profile of this regimen, as well as the prognostic factors in predicting tumor response to this regimen. With the emergence of new, active compounds for metastatic CRC, a simple 2-hour infusion of oxaliplatin plus 46-hour infusion of 5-FU/LV every 2 weeks has become a favorable regimen, with an overall response rate (ORR) of 40%-50% and overall survival of 18.2 months in chemotherapy-naive patients. Conversely, there were also studies to suggest that biweekly oxaliplatin plus weekly or biweekly bolus 5-FU/LV was shown to ach...Continue Reading

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Citations

Apr 28, 2006·Journal of Gastroenterology and Hepatology·Her-Shyong ShiahLi-Tzong Chen
Sep 10, 2014·International Journal of Molecular Medicine·Yu-Chieh SuShih-Kai Hung
Feb 23, 2013·International Journal of Molecular Sciences·Ming-Yii HuangShiu-Ru Lin
Jun 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Ching-Bin LinGregory J Tsay
Jul 10, 2012·International Journal of Colorectal Disease·Shih-Yung SuYung-Po Liaw
Oct 15, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ming-Hung TsaiJau-Song Yu

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