PMID: 9442447Jan 27, 1998Paper

Current status of conducting function tests in repeated dose toxicity studies in Japan

The Journal of Toxicological Sciences
T MatsuzawaT Igarashi

Abstract

It seems desirable to conduct as many function tests as possible in repeated dose toxicity studies, but is it practicable? The current status of conducting function tests in repeated dose toxicity studies in Japan was investigated by a literature survey of more than one thousand papers published in seven Japanese toxicology journals during the past 10 years and by a questionnaire survey directed to toxicologists among the Japan Pharmaceutical Manufacturers Association (JPMA) member companies. The function tests often carried out in repeated dose toxicity studies were, for example: 1) electro-retinography (ERG) and visually evoked potential (VEP) for visual test and tonometer for intraocular pressure; 2) auricular reflex, evoked response audiometry (ERA) and auditory brainstem response (ABR) to sound stimuli; 3) respiration and heart rate, electrocardiogram (ECG) and blood pressure by noninvasive cuff methods or using electronic devices such as telemetry; 4) body temperature, spontaneous motility and some adaptation tests (using rotarod and sloped plate in rats); 5) indocyanin (ICG) or bromosulfophtalein (BSP) for hepatic test; 6) phenolsulfonphtalein (PSP) and creatinine clearance for renal test; and 7) immunoglobulin, leukocyt...Continue Reading

Citations

Feb 27, 2013·Journal of Pharmacological and Toxicological Methods·Theodore J BairdJill A Dalton
Apr 30, 2014·Journal of Applied Toxicology : JAT·Varun Ahuja, Sharad Sharma
Jun 6, 2015·Journal of Pharmacological and Toxicological Methods·David V GauvinTheodore J Baird

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