Current status of endoscopic balloon dilation for Crohn's disease

Intestinal research
Fumihito Hirai

Abstract

The therapeutic target in Crohn's disease (CD) has been raised to the achievement of mucosal healing. Although effective treatments that target cytokines and other molecules has been widely used for CD, intestinal strictures are still a major cause of surgery. Endoscopic balloon dilation (EBD) is known to be an effective and safe intervention for intestinal strictures in CD. Since frequent intestinal resection often results in short bowel syndrome and can decrease the quality of life, EBD can help avoid surgery. EBD with a conventional colonoscope for Crohn's strictures of the colon and ileo-colonic anastomosis has established efficacy and safety. In addition, EBD using balloon-assisted enteroscopy has recently been applied for small bowel Crohn's strictures. Although the evidence is not strong, EBD may become an alternative to surgery in small bowel strictures in CD. EBD and other new methods such as self-expanding stent implantation for Crohn's strictures may be useful and safe; however, it is important to address several issues regarding these interventions and to establish a protocol for combined therapies.

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Citations

Oct 12, 2017·Clinical Endoscopy·Thomas KlagMartin Goetz
Mar 5, 2020·Journal of Gastroenterology·Kento TakenakaKazuo Ohtsuka
Apr 13, 2020·Digestive Diseases and Sciences·Mattia CrespiMassimo Conio
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Mar 20, 2021·Digestive Diseases and Sciences·Hyun Seok LeeAndrew Ross
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Jun 30, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Teruyuki TakedaKenshi Yao
Nov 25, 2020·Intestinal research·Giuseppe Cicero, Silvio Mazziotti

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