Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer

Cells
N SobhaniD Generali

Abstract

Breast cancer (BC) is the most common malignancy and second only to lung cancer in terms of mortality in women. Despite the incredible progress made in this field, metastatic breast cancer has a poor prognosis. In an era of personalized medicine, there is an urgent need for better knowledge of the biology leading to the disease, which can lead to the design of increasingly accurate drugs against patients' specific molecular aberrations. Among one of the actionable targets is the fibroblast growth factor receptor (FGFR) pathway, triggered by specific ligands. The Fibroblast Growth Factor Receptors/Fibroblast Growth Factors (FGFRs/FGFs) axis offers interesting molecular targets to be pursued in clinical development. This mini-review will focus on the current knowledge of FGFR mutations, which lead to tumor formation and summarizes the state-of-the-art therapeutic strategies for targeted treatments against the FGFRs/FGFs axis in the context of BC.

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Methods Mentioned

BETA
xenograft
PCR

Clinical Trials Mentioned

NCT01004224
NCT01928459
NCT01791985
NCT03238196
NCT01528345
NCT02202746
NCT02619162
NCT00687505

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