Current Status of HDAC Inhibitors in Cutaneous T-cell Lymphoma

American Journal of Clinical Dermatology
Adriana T LopezLarisa Geskin

Abstract

Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of lymphomas that are characterized by primary skin involvement. Mycosis fungoides (MF) and Sézary syndrome (SS), the two most common subtypes of CTCL, can be difficult to manage clinically as there are few effective treatment options available. Recently, histone deacetylase inhibitors (HDACi) have emerged as promising therapies with favorable adverse effect profiles, compared with traditional chemotherapies. In this article, we review the published literature to evaluate the role of HDACi in the treatment of CTCL. Specifically, we (1) briefly discuss the molecular rationale for the use of HDACi in CTCL; (2) compare the efficacy, tolerability, and adverse effects of HDACi; (3) review the cardiac safety data; and (4) discuss optimization of therapy with HDACi in the treatment of CTCL.

References

Jan 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E C KohnD C Ihde
Feb 5, 1987·The New England Journal of Medicine·R EdelsonG Plewig
Nov 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R T HoppeN M Price
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonG P Canellos
Dec 2, 1999·Experimental Cell Research·C Schindler
Aug 3, 2000·Journal of the National Cancer Institute·P A MarksR A Rifkind
Sep 6, 2000·Dermatology : International Journal for Clinical and Investigative Dermatology·M M Morales Suárez-VarelaJ Bell
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E OlsenJ Nichols
May 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M DuvicUNKNOWN Bexarotene Worldwide Study Group
Oct 12, 2001·Annals of the New York Academy of Sciences·P Heald
Aug 3, 2002·Leukemia & Lymphoma·Matt MorganMadeleine Duvic
Aug 13, 2004·Current Cardiology Reports·Deborah L Wolbrette
Nov 3, 2004·Nature Reviews. Molecular Cell Biology·Stefan J Riedl, Yigong Shi
Jan 18, 2005·Journal of Cell Science·Inna LavrikPeter H Krammer
May 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kapil N Bhalla
May 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William Kevin KellyVictoria M Richon
May 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Remco van DoornCornelis P Tensen
Nov 26, 2005·Expert Opinion on Investigational Drugs·Paul A Marks, Milos Dokmanovic
Jun 17, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard L PiekarzSusan E Bates
Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Manisha H ShahMichael Grever
Jul 25, 2006·Clinical Genitourinary Cancer·Walter M StadlerJohn A Thompson
Aug 2, 2006·Clinical Lymphoma & Myeloma·Madeleine DuvicNarin Apisarnthanarax
Sep 7, 2006·Nature Reviews. Drug Discovery·Jessica E BoldenRicky W Johnstone
Jan 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonUNKNOWN International Harmonization Project on Lymphoma
May 15, 2007·Biochemical Pharmacology·Keith B Glaser
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elise A OlsenMadeleine Duvic
Jul 20, 2007·Archives of Dermatology·Vincent D Criscione, Martin A Weinstock
Sep 7, 2007·Journal of the American Society of Nephrology : JASN·Chou-Long Huang, Elizabeth Kuo
Oct 7, 2008·Journal of the American Academy of Dermatology·Victoria NguyenJoan Guitart

❮ Previous
Next ❯

Citations

Jun 23, 2020·Oncology Letters·Malgorzata BobrowiczMagdalena Winiarska
Mar 20, 2019·Journal of Hematology & Oncology·Marion WobserRoland Houben
Dec 21, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Megan H Trager, Larisa J Geskin
Jun 14, 2019·Frontiers in Medicine·Tomonori Oka, Tomomitsu Miyagaki
Apr 24, 2021·Expert Review of Clinical Immunology·Antreas PavlidisEvangelia Papadavid
Jul 13, 2021·Frontiers in Oncology·Ping Zhang, Mingzhi Zhang
May 30, 2021·Molecular Cancer Research : MCR·Maryam SafariSusan E Bates
Apr 27, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Maria GluudLise M Lindahl
Apr 27, 2021·International Journal of Women's Dermatology·Jordan T SaidSteven T Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Related Papers

Journal of Hematology & Oncology
Salvia JainOwen O'Connor
Seminars in Oncology
Madeleine Duvic, Francine M Foss
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
E C BentonS J Whittaker
Journal of the American Academy of Dermatology
Rakhshandra TalpurMadeleine Duvic
© 2022 Meta ULC. All rights reserved