Current status of intramyocardial bone marrow stem cell transplantation

Seminars in Thoracic and Cardiovascular Surgery
Alexander Kaminski, Gustav Steinhoff

Abstract

Since the first reports of the capacity of bone marrow stem cells for use in cardiac repair and regeneration after acute myocardial infarction, today, the therapeutic strategy of direct cell administration during cardiac surgery is entering clinical practice. Here we report on the current knowledge of the "new cellular tool" in the cardiac surgeon's hands that is enabling them to exceed the limits of modern methods for myocardial revascularization and repair in cardiac surgery. Therefore, we discuss preclinical data focusing on bone marrow stem cell types and point to the current mechanistic explanation of their effects. With 7 years' experience after completing Phase I and Phase II clinical trials with cardiac transplantation of autologous intramyocardial bone marrow stem cells, we draw conclusions about surgical applicability, safety, and efficacy. At present, the functional effects of this treatment are highly promising to become a standard treatment. Further clarification by prospective randomized clinical Phase III trials is necessary in this field.

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Citations

Jun 23, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Chung-Yi YangHon-Man Liu
Mar 8, 2011·The Journal of Thoracic and Cardiovascular Surgery·Peter DonndorfAenne Glass
May 18, 2010·Journal of the American Academy of Dermatology·Klaus Sellheyer, Dieter Krahl
Sep 3, 2011·Journal of the American College of Cardiology·Bodo-Eckehard Strauer, Gustav Steinhoff
Oct 5, 2014·Asian Cardiovascular & Thoracic Annals·Sadeq Ali-Hasan-Al-SaeghAron-Frederik Popov
Sep 11, 2010·Interactive Cardiovascular and Thoracic Surgery·Peter DonndorfAndreas Liebold

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