Current status of mesenchymal stem cell therapy for immune/inflammatory lung disorders: Gleaning insights for possible use in COVID-19

Stem Cells Translational Medicine
B Linju YenHuey-Kang Sytwu

Abstract

The broad immunomodulatory properties of human mesenchymal stem cells (MSCs) have allowed for wide application in regenerative medicine as well as immune/inflammatory diseases, including unmatched allogeneic use. The novel coronavirus disease COVID-19 has unleashed a pandemic in record time accompanied by an alarming mortality rate mainly due to pulmonary injury and acute respiratory distress syndrome. Because there are no effective preventive or curative therapies currently, MSC therapy (MSCT) has emerged as a possible candidate despite the lack of preclinical data of MSCs for COVID-19. Interestingly, MSCT preclinical data specifically on immune/inflammatory disorders of the lungs were among the earliest to be reported in 2003, with the first clinical use of MSCT for graft-vs-host disease reported in 2004. Since these first reports, preclinical data showing beneficial effects of MSC immunomodulation have accumulated substantially, and as a consequence, over a third of MSCT clinical trials now target immune/inflammatory diseases. There is much preclinical evidence for MSCT in noninfectious-including chronic obstructive pulmonary disease, asthma, and idiopathic pulmonary fibrosis-as well as infectious bacterial immune/inflammato...Continue Reading

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Sep 9, 2020·Stem Cell Reviews and Reports·José Lucas Martins RochaKelen Cristina Ribeiro Malmegrim
Jan 10, 2021·Stem Cell Reviews and Reports·Lacy E LowryJames A Bynum
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Jun 25, 2021·Stem Cells Translational Medicine·José Becerra, Ivan Duran
Aug 13, 2021·Science Advances·Mark M ZakiGeorge M Church

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Methods Mentioned

BETA
lavage

Clinical Trials Mentioned

NCT04282928
NCT04289194
NCT04347967

Software Mentioned

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