Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders.

Cells
Sujay PaulAshutosh Sharma

Abstract

MicroRNAs (miRNAs) are a key gene regulator and play essential roles in several biological and pathological mechanisms in the human system. In recent years, plenty of miRNAs have been identified to be involved in the development of neurodegenerative disorders (NDDs), thus making them an attractive option for therapeutic approaches. Hence, in this review, we provide an overview of the current research of miRNA-based therapeutics for a selected set of NDDs, either for their high prevalence or lethality, such as Alzheimer's, Parkinson's, Huntington's, Amyotrophic Lateral Sclerosis, Friedreich's Ataxia, Spinal Muscular Atrophy, and Frontotemporal Dementia. We also discuss the relevant delivery techniques, pertinent outcomes, their limitations, and their potential to become a new generation of human therapeutic drugs in the near future.

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Citations

Nov 13, 2020·3 Biotech·Sujay PaulAashish Srivastava
Jan 19, 2021·Archives of Biochemistry and Biophysics·Sujay PaulAashish Srivastava
Feb 13, 2021·Biomolecules·Matea Nikolac PerkovicNela Pivac
Jan 6, 2021·Stem Cell Reviews and Reports·Zafer CetinEmel Sokullu
Apr 8, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Pragnya DasVineet Bhandari
May 3, 2021·Cellular and Molecular Neurobiology·Islauddin KhanShashi Bala Singh
May 10, 2021·Free Radical Biology & Medicine·Gabriel Palermo RuizMarcelo A Mori
Jun 8, 2021·Leukemia & Lymphoma·Karolina ŁuczkowskaBogusław Machaliński
May 21, 2021·Journal of the Neurological Sciences·Gayatri GandhiWendy Wai Yeng Yeo
Feb 28, 2021·Journal of Neurochemistry·Santosh R D'Mello

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Methods Mentioned

BETA
transfection
transgenic
biopsies
SMA

Software Mentioned

FRDA

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