Current Status of Multiple Drug Molecules, and Vaccines: An Update in SARS-CoV-2 Therapeutics

Molecular Neurobiology
Ramesh KandimallaP Hemachandra Reddy

Abstract

The coronavirus disease of 2019 (COVID-19) is a pandemic disease that has taken the lives of many around the world. It is caused by severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2). To date, the USA, Italy, Spain, France, Russia, and the UK have been hit the hardest by the virus. However, death counts are still rising. Some nations have managed to "flatten" the death rate via protective measures such physical distancing, quarantine measures, and therapeutic management. The structure of the SARS-CoV-2 virus comprises of S proteins, M proteins, E proteins, hemagglutinin esterases, nucleocapsid proteins, and a 30-kb RNA genome. Viral proteases cleave these polyproteins and RNA-dependent polymerases replicate the genome. Currently, there are no effective therapies against this new disease. Numerous investigators are developing novel protease inhibitors, some of which have made it into clinical trials. Researchers are also attempting to develop a vaccine. In this review paper, we discuss the latest therapeutic developments against COVID-19. Graphical Abstract.

References

Oct 1, 1990·Epidemiology and Infection·K A CallowD A Tyrrell
Sep 14, 2006·PLoS Medicine·Lauren J StockmanPaul Garner
Mar 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alenka KuznikRoman Jerala
Oct 18, 2011·The Journal of Rheumatology·Alla OsadchyGideon Koren
Dec 2, 2014·The Lancet Infectious Diseases·France MentréDenis Malvy
Feb 28, 2015·Nature Reviews. Drug Discovery·Florian Krammer, Peter Palese
Mar 31, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie AnKeith B Elkon
Aug 27, 2015·International Journal of Clinical Pharmacology and Therapeutics·Yuji KumagaiAkiko Kaneko
Dec 29, 2017·PLoS Neglected Tropical Diseases·Pierangelo ChinelloUNKNOWN INMI Ebola Team
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Feb 26, 2020·Pharmacology & Therapeutics·Kimiyasu Shiraki, Tohru Daikoku
Feb 28, 2020·JAMA : the Journal of the American Medical Association·Lan LanHaibo Xu
Mar 8, 2020·Travel Medicine and Infectious Disease·Jaffar A Al-TawfiqZiad A Memish
Mar 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xueting YaoDongyang Liu
Mar 17, 2020·International Journal of Antimicrobial Agents·Christian A DevauxDidier Raoult
Mar 19, 2020·The New England Journal of Medicine·Bin CaoChen Wang
Mar 21, 2020·The Journal of Antimicrobial Chemotherapy·Dan ZhouQiang Tong
Mar 21, 2020·The Lancet. Gastroenterology & Hepatology·Yong XiaoMingkai Chen
Mar 25, 2020·International Journal of Antimicrobial Agents·Philippe GautretDidier Raoult
Mar 26, 2020·JAMA : the Journal of the American Medical Association·Andre C Kalil
Apr 3, 2020·BMJ : British Medical Journal·Jeanne Lenzer
Apr 8, 2020·Journal of Medical Virology·Pan LuoJuan Li
Apr 8, 2020·Immunity·Fatima Amanat, Florian Krammer
Apr 14, 2020·JAMA : the Journal of the American Medical Association·James M SandersJames B Cutrell
Apr 15, 2020·Nature Medicine·Kristian G AndersenRobert F Garry
Apr 16, 2020·Journal of Translational Medicine·Binqing FuHaiming Wei
Jun 2, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Sandra De MeyerSandra Ciesek
Jun 28, 2020·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Sebastian Neumann-BöhmeTom Stargardt
Mar 27, 2020·MedRxiv : the Preprint Server for Health Sciences·H.-w. JiangSheng-ce Tao

❮ Previous
Next ❯

Citations

Sep 29, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Katherine Holder, P Hemachandra Reddy
Nov 18, 2020·Computational and Structural Biotechnology Journal·Masaud ShahHyun Goo Woo
Jan 30, 2021·Frontiers in Aging Neuroscience·Riya Ganji, P Hemachandra Reddy
Feb 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Peyman Kheirandish ZarandiNima Rezaei
Dec 29, 2020·Human Vaccines & Immunotherapeutics·Ma Sophia Graciela L ReyesBeverly Lorraine Ho
Dec 29, 2020·Infection and Drug Resistance·Rimple Jeet KaurSanjeev Misra
Aug 23, 2020·Microorganisms·Qingxin Li, CongBao Kang
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohd SaeedMousa Alreshidi
May 14, 2021·Clinical Microbiology Reviews·Seyed Hamid Safiabadi TaliSana Jahanshahi-Anbuhi
May 23, 2021·Human Immunology·Abhigyan ChoudhurySuprabhat Mukherjee
May 25, 2021·Frontiers in Medicine·Mirjam KienerMarianna Kruithof-de Julio
Aug 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ming-Shao TsaiChing-Yuan Wu
Sep 14, 2021·Chemical Physics·Yamini Thakur, Rama Pande

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation
ELISA
flow cytometry

Clinical Trials Mentioned

NCT04323527
NCT04261517
NCT04303507
NCT04252274
NCT04252664
NCT04280705
NCT04257656
NCT04292730
NCT04302766
NCT04292899

Software Mentioned

Ervebo
NOVAVAX

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved