Current status of perioperative chemotherapy for locally advanced gastric cancer and JCOG perspectives

Japanese Journal of Clinical Oncology
Masanori TerashimaStomach Cancer Study Group, Japan Clinical Oncology Group

Abstract

Perioperative treatment for locally advanced gastric cancer has been inconsistent between Japan and the Western countries. In Japan, D2 gastrectomy followed by adjuvant chemotherapy is regarded as standard treatment, while neoadjuvant or perioperative chemotherapy is considered to be a standard in the Western countries. Stomach Cancer Study Group of Japan Clinical Oncology Group (JCOG) has conducted many perioperative chemotherapy trials. After the publishing of positive results of ACTS-GC trial, stage-specific adjuvant chemotherapy protocols are planned. JCOG1104 was conducted as to demonstrate the non-inferiority of four courses of S-1 to standard eight courses of S-1, because the efficacy of S-1 appears to be sufficient in stage II. The trial failed to demonstrate the non-inferiority of four courses of S-1. S-1 for 1 year is still recognized to be a standard for stage II gastric cancer. For stage III, studies with more intensive treatments were planned as the efficacy of S-1 monotherapy seems to be insufficient. As in the Western countries, JCOG planned the perioperative chemotherapy. However, the clinical staging is a serious issue to select optimal patients for perioperative chemotherapy. JCOG conducted a prospective cohor...Continue Reading

References

Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi NashimotoUNKNOWN Gastric Cancer Surgical Study Group, Japan Clinical Oncology Group
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Nov 6, 2007·The New England Journal of Medicine·Shinichi SakuramotoUNKNOWN ACTS-GC Group
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Aug 1, 2009·The British Journal of Surgery·T YoshikawaN Fukushima
Feb 22, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Isao MiyashiroUNKNOWN Gastric Cancer Surgical Study Group in the Japan Clinical Oncology Group
Oct 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitsuru SasakoYasuo Ohashi
Feb 13, 2013·Journal of Surgical Oncology·Yoshiaki IwasakiUNKNOWN Gastric Cancer Surgical Study Group of Japan Clinical Oncology Group
Mar 29, 2014·The British Journal of Surgery·A TsuburayaUNKNOWN Stomach Cancer Study Group of the Japan Clinical Oncology Group
Jun 15, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Seiji ItoMitsuru Sasako
Feb 15, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Takeo FukagawaUNKNOWN Stomach Cancer Study Group of the Japan Clinical Oncology Group
Mar 4, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Masanori TerashimaUNKNOWN Stomach Cancer Study Group, Japan Clinical Oncology Group
Mar 30, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kazuhiro YoshidaMasashi Fujii
Sep 14, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Daisuke TakahariUNKNOWN Stomach Cancer Study Group of the Japan Clinical Oncology Group

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Citations

Dec 29, 2020·Japanese Journal of Clinical Oncology·Hideo Kunitoh
Mar 2, 2021·World Journal of Gastroenterology : WJG·Masahiro YuraMotohito Nakagawa

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