Current status of PET imaging in Huntington's disease.

European Journal of Nuclear Medicine and Molecular Imaging
Gennaro PaganoMarios Politis

Abstract

To review the developments of recent decades and the current status of PET molecular imaging in Huntington's disease (HD). A systematic review of PET studies in HD was performed. The MEDLINE, Web of Science, Cochrane and Scopus databases were searched for articles in all languages published up to 19 August 2015 using the major medical subject heading "Huntington Disease" combined with text and key words "Huntington Disease", "Neuroimaging" and "PET". Only peer-reviewed, primary research studies in HD patients and premanifest HD carriers, and studies in which clinical features were described in association with PET neuroimaging results, were included in this review. Reviews, case reports and nonhuman studies were excluded. A total of 54 PET studies were identified and analysed in this review. Brain metabolism ([(18)F]FDG and [(15)O]H2O), presynaptic ([(18)F]fluorodopa, [(11)C]β-CIT and [(11)C]DTBZ) and postsynaptic ([(11)C]SCH22390, [(11)C]FLB457 and [(11)C]raclopride) dopaminergic function, phosphodiesterases ([(18)F]JNJ42259152, [(18)F]MNI-659 and [(11)C]IMA107), and adenosine ([(18)F]CPFPX), cannabinoid ([(18)F]MK-9470), opioid ([(11)C]diprenorphine) and GABA ([(11)C]flumazenil) receptors were evaluated as potential biomarker...Continue Reading

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Citations

Jun 29, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Diego Alfonso López-MoraIgnasi Carrió
Jul 30, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Flavia Niccolini, Marios Politis
Sep 17, 2016·Mechanisms of Ageing and Development·Aris A Polyzos, Cynthia T McMurray
Jun 8, 2017·Brain Sciences·Ryoma Morigaki, Satoshi Goto
Feb 15, 2017·Frontiers in Neurology·Heather WilsonMarios Politis
Feb 22, 2018·CNS Neuroscience & Therapeutics·Maurice GarretJérôme Baufreton
Aug 8, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Yi-Ting HsuYijuang Chern
Dec 22, 2017·Journal of Neural Transmission·Gennaro PaganoMarios Politis
Jan 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Klaudia CybulskaMark Rijpkema
Sep 11, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Flavia NiccoliniMarios Politis
Oct 5, 2017·Current Neurology and Neuroscience Reports·Gennaro PaganoMarios Politis
Mar 8, 2017·Current Neurology and Neuroscience Reports·Tiago A Mestre, Cristina Sampaio
Oct 7, 2018·Current Neurology and Neuroscience Reports·Patrik FazioAndrea Varrone
Oct 17, 2018·Frontiers in Neurology·Tayyabah YousafMarios Politis
Jan 11, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Frederic SampedroJaime Kulisevsky
Dec 19, 2016·Drugs·Emma M Coppen, Raymund A C Roos
Aug 17, 2019·Pediatric Neurology·Harry T Chugani
Nov 26, 2020·International Journal of Molecular Sciences·Nicole Jacqueline JensenJørgen Rungby
Apr 24, 2021·Journal of the Neurological Sciences·Antía Reguera AcuñaVictoria Álvarez Martínez
May 1, 2021·AJNR. American Journal of Neuroradiology·J D OldanT Z Wong
May 25, 2018·Behavioural Brain Research·Emma M CoppenRaymund A C Roos
Jul 24, 2021·Clinical Case Reports·Martin Schulze WesthoffAdrian Groh
May 4, 2018·ACS Chemical Neuroscience·Cristina LoisH Diana Rosas

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Methods Mentioned

BETA
imaging techniques

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