Current Status of the Third-Line Helicobacter pylori Eradication

Gastroenterology Research and Practice
Jae Ho ChoiGwang Ho Baik

Abstract

Antibiotic resistance is growing worldwide, and patients who have failed consecutive 1st- and 2nd-line H. pylori eradication regimens are increasing. Therefore, the role of the bacterial culture with antibiotic susceptibility testing and molecular susceptibility testing is important for avoiding the use of ineffective antibiotics. However, antibiotic susceptibility testing-guided treatment does not necessarily guarantee successful eradication, and there have been mixed results for the effectiveness of a 3rd-line rescue therapy. Therefore, providing patients with pretreatment medication instructions and education is important. It is also crucial to determine the reason of the eradication failure, including host-related factors (poor compliance to eradication regimen, smoking, and cytochrome P450 2C19 genetic polymorphism) or treatment-related factors (inadequate dosage or duration of therapy and gastric acidity), as such factors can be modified for a tailored therapy. Although the indications for H. pylori eradication have widened, patients at a high risk of gastric cancer can gain definitive benefits with a 3rd-line or even 4th-line therapy.

References

May 29, 1999·Antimicrobial Agents and Chemotherapy·M HeepN Lehn
Sep 7, 2000·Current Pharmaceutical Design·D Y Graham, W A Qureshi
Sep 15, 2001·The New England Journal of Medicine·N UemuraR J Schlemper
Feb 4, 2006·The American Journal of Gastroenterology·Javier P GisbertUNKNOWN H. pylori Study Group of the Asociación Española de Gastroenterología
Oct 28, 2006·The Lancet Infectious Diseases·Monique M GerritsJohannes G Kusters
Apr 13, 2007·Clinical Microbiology Reviews·Francis Mégraud, Philippe Lehours
May 1, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·David Y Graham, Akiko Shiotani
Feb 4, 2009·Antimicrobial Agents and Chemotherapy·Hidekazu SuzukiToshifumi Hibi
Sep 17, 2009·Journal of Infection in Developing Countries·Abdoulaye SeckCheikh Saad-Bouh Boye
Mar 23, 2010·Helicobacter·Masahiro AsakaUNKNOWN Japanese Society for Helicobacter Research
Mar 17, 2011·Nature Reviews. Microbiology·Aymé SporRuth Ley
Aug 30, 2011·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jae Yeon KimIn Sung Song
Sep 8, 2011·Antimicrobial Agents and Chemotherapy·Toshihiro NishizawaToshifumi Hibi
Dec 2, 2011·Alimentary Pharmacology & Therapeutics·J P Gisbert, X Calvet
Apr 27, 2012·Gastroenterology Research and Practice·Javier P Gisbert
Oct 27, 2012·The Journal of Antimicrobial Chemotherapy·Jyh-Ming LiouUNKNOWN Taiwan Helicobacter Consortium
Dec 5, 2012·The American Journal of Gastroenterology·Amnon Sonnenberg, Robert M Genta
Jan 12, 2013·Journal of Gastroenterology·Kazunari MurakamiUNKNOWN Japan GAST Study Group
Mar 7, 2013·The Journal of Antimicrobial Chemotherapy·Nicole WueppenhorstErik-Oliver Glocker
May 24, 2013·The New England Journal of Medicine·Sally P Stabler
May 24, 2013·The New England Journal of Medicine·John Paul Killen, Vanessa L Brenninger
May 24, 2013·The New England Journal of Medicine·Chady Abboud LeonWissam Zaeeter
Jul 19, 2013·European Journal of Gastroenterology & Hepatology·Michael SelgradPeter Malfertheiner
Dec 24, 2013·World Journal of Gastroenterology : WJG·Enzo IerardiMariabeatrice Principi
Mar 22, 2014·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Sun Young Lee
Apr 25, 2014·Journal of Gastroenterology and Hepatology·Sang Gyun KimUNKNOWN Korean College of Helicobacter and Upper Gastrointestinal Research
May 17, 2014·World Journal of Gastroenterology : WJG·Giovanni CammarotaAntonio Gasbarrini
Aug 12, 2014·World Journal of Gastroenterology : WJG·Sinéad M SmithDeirdre McNamara
Jun 17, 2015·The Journal of Antimicrobial Chemotherapy·Sheila López-GóngoraJavier P Gisbert
Jul 19, 2015·Gut·Kentaro SuganoUNKNOWN faculty members of Kyoto Global Consensus Conference
Oct 16, 2015·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·W ElMaraachliT C Rodwell
Nov 11, 2015·The Korean Journal of Internal Medicine·Chang Seok Bang, Gwang Ho Baik
Apr 23, 2016·Gastroenterology·Carlo A FalloneJohn K Marshall
Jul 2, 2016·Therapeutic Advances in Gastroenterology·Ignasi PuigJavier P Gisbert

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